SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report


Report for Clinical Trial NCT03874455

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

Tazemetostat Expanded Access Program for Adults With Solid Tumors

Patients with following conditions are eligible to enroll in the EAP: - Epithelioid Sarcoma (ES) - Spindle cell sarcoma - Sinonasal carcinoma - Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) - Thoracic sarcoma - Poorly differentiated chordoma These conditions must be serious or life-threatening at the time of enrollment and appropriate, comparable, or satisfactory alternative treatments must have been tried without clinical success. Patients with conditions not listed above are not eligible for the tazemetostat EAP

NCT03874455 Epithelioid Sarcoma Spindle Cell Sarcoma Sinonasal Carcinoma Small Cell Carcinoma of the Ovary Hypercalcemic Type Thoracic Sarcoma Poorly Differentiated Chordoma
MeSH: Carcinoma Sarcoma Chordoma Carcinoma, Small Cell Small Cell Lung Carcinoma Carcinoma, Ovarian Epithelial
HPO: Carcinoma Chordoma Sarcoma Small cell lung carcinoma Soft tissue sarcoma

1 Interventions

Name: Tazemetostat

Description: Tazemetostat (EPZ-6438) is a selective small molecule inhibitor of the histone-lysine methyltransferase EZH2 gene

Type: Drug



There is one SNP

SNPs


1 V617F

JAK2 V617F) observed in cytogenetic testing and DNA sequencing. --- V617F ---



HPO Nodes


HPO:
Carcinoma
Genes 11
PTEN CDKN1B APC MLH1 MSH2 FGFR3 KIT DKC1 RSPO1 STK11 NLRP1
Chordoma
Genes 2
TSC1 TSC2
Sarcoma
Genes 116
VEGFC CDKN1A CDKN1B FOXO1 CDKN2A KRAS CDKN2B CDKN2C GDF5 FLNA ATP6V1B2 PMS2 FLT4 NRAS KRT17 PDGFB PDGFRA RB1 PDGFRB SRC MC1R WRN WT1 APC CASP10 NBN GJC2 NR4A3 RPS19 TSC1 TSC2 EWSR1 EXT1 EXT2 MSH2 KEAP1 IDH1 IDH2 REST DCC PTCH1 PTEN MDM2 FAS FASLG SSX1 SSX2 TRIP13 DICER1 PTH1R AXIN2 MEN1 NUTM1 TBX18 SLC22A18 MSH6 RASGRP1 FAM20C BMPR1A BMPR1B KLLN PTPN11 DLC1 MTAP NF1 ANTXR2 LMNA BRAF NF2 ABCA5 PIK3CA KCNH1 ELMO2 SQSTM1 BRD4 DHCR24 RECQL4 BUB1 BUB1B CHEK2 HRAS PTCH2 MLH1 PRKAR1A FLCN PRKCD SPRED1 AKT1 ASPSCR1 TAF15 FGFR3 PAX3 PLCD1 CDC73 GREM1 PAX7 GNAS CTNNB1 FH BUB3 SUFU MAP2K1 CEP57 KIT EP300 PRLR SEC23B SDHA TP53 NOTCH3 SDHB SDHC SDHD COL1A1 SOS1 FOXC2
Small cell lung carcinoma
Soft tissue sarcoma
Genes 91
VEGFC CDKN1A CDKN1B FOXO1 KRAS CDKN2B CDKN2C SLC22A18 FLNA MSH6 RASGRP1 ATP6V1B2 FAM20C BMPR1A PMS2 FLT4 KLLN PTPN11 DLC1 MTAP NF1 ANTXR2 NRAS KRT17 BRAF NF2 PDGFB PDGFRA ABCA5 PDGFRB PIK3CA KCNH1 ELMO2 DHCR24 SRC BUB1 BUB1B MC1R HRAS PTCH2 APC MLH1 PRKAR1A FLCN CASP10 NBN PRKCD SPRED1 GJC2 AKT1 TSC1 TSC2 ASPSCR1 MSH2 FGFR3 PAX3 PLCD1 CDC73 KEAP1 GREM1 PAX7 REST CTNNB1 DCC FH PTCH1 BUB3 PTEN FAS FASLG SUFU MAP2K1 SSX1 SSX2 CEP57 TRIP13 KIT DICER1 EP300 PRLR SEC23B TP53 NOTCH3 SDHB SDHC SDHD AXIN2 COL1A1 MEN1 SOS1 FOXC2