SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report

Report for Clinical Trial NCT02628314

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

Reliability of Pupil Response to Acute Pain

The purpose of this research study is to test whether researchers can reliably measure the response pupils have when an acute painful stimulus is experienced. Changes in the size of the pupil of the eye can be an indicator of brain activity in a region of the brain that is important for feeling pain.

NCT02628314 Pain Osteoarthritis
MeSH: Osteoarthritis Acute Pain
HPO: Osteoarthritis

Primary Outcomes

Measure: Change from Baseline Verbal Pain Scores

Time: 8 weeks

Description: pupil diameter in response to 5 second presentation of noxious heat stimuli

Measure: Percentage of change in pupil diameter

Time: 8 weeks
Time Perspective: Prospective

Cohort

There is one SNP

SNPs

1 V158M

Key secondary hypotheses: Compared to individuals homozygous for val at the val158met site of the catecholamine-O-methyltransferase (COMT) gene, those homozygous for met will show smaller pupil responses to noxious stimuli and weaker CPM. --- val158met ---


HPO Nodes

HPO:
Osteoarthritis
Genes 52
COL2A1 COL3A1 GHR PHEX TGFB3 CCN6 GDF5 COL5A1 HGD COL5A2 COL9A1 COL9A2 COL9A3 COL11A1 COL11A2 FBN1 ATP7B ZMPSTE24 UFSP2 COMP LMNA CLCN7 AEBP1 CANT1 LMX1B SLC26A2 ACAN HPGD MATN3 SCARB2 TRPS1 GBA TRPV4 EXT1 EXT2 FGFR3 AIP GNAS GPR101 MMP13 ANKH TNXB F8 SLC40A1 F9 MEFV ZNF687 SMAD3 KIF22 KIF7 COL1A1 TRAPPC2