Hereditary haemochromatosis (HHC) is a frequent disease in Brittany (5 to 7‰), responsible first for biological disorder in blood iron parameters and minor clinical disorders, before evolving to potential life-threatening consequences such as diabetes, liver cirrhosis and congestive heart failure. The improvement of screening and treatments made those severe affections rare enough not to evaluate myocardial iron overload a systematic part of the starting check-up. Nonetheless this myocardial iron overload might have severe implications on cardiac function on a long term basis. A single trial was conducted on limited number of patients with 1.5 Tesla MRI, which showed a myocardial iron overload (defined by a myocardium T2* value <20ms) in 19% of the subjects. The main objective of this study is to precisely estimate cardiac iron overload in treatment naive patients with newly diagnosed HFE hereditary haemochromatosis with a 3 Tesla MRI, more sensitive than the 1.5 Tesla one, in order to later appreciate its correlation with cardiac morbidity in HHC.
Name: 3Tesla cardiac MRI
Type: DevicePatients with HFE hereditary haemochromatosis Healthy volunteers
Name: Electrocardiogram (EKG)
Type: DevicePatients with HFE hereditary haemochromatosis
Name: Iron and cardiac markers
Description: Serum iron, serum transferrin, transferrin saturation, serum ferritin, NT-proBNPType: BiologicalPatients with HFE hereditary haemochromatosis
Name: Pregnancy test
Description: Beta-hCGType: BiologicalPatients with HFE hereditary haemochromatosis
Name: Echocardiography at rest
Description: Transthoracic echocardiographType: DevicePatients with HFE hereditary haemochromatosis Healthy volunteers
Name: Urinary pregnancy test
Type: BiologicalHealthy volunteers
Name: 3Tesla abdominal MRI
Type: DevicePatients with HFE hereditary haemochromatosis
Description: Assessment of the percentage rate of patients presenting a lower T2* value than the baseline defined by the mean of T2* values measured in healthy volunteers with a 1 standard deviation margin.
Measure: Myocardial T2* values in haemochromatosis compared to healthy volunteers Time: Day 1Description: Comparison of the mean T2 values in healthy volunteers and patients with HFE-related haemochromatosis
Measure: Mean T2 values in healthy volunteers and patients with HFE-related haemochromatosis Time: Day 1Description: Correlation between liver T2/T2* and myocardial T2/T2*
Measure: Liver T2/T2* values Time: Day 1Description: Correlation between pancreas T2/T2* and myocardial T2/T2*
Measure: Pancreas T2/T2* values Time: Day 1Description: Correlation between spleen T2/T2* and myocardial T2/T2*
Measure: Spleen T2/T2* values Time: Day 1Allocation: Non-Randomized
Parallel Assignment
There is one SNP
Inclusion Criteria: Patients : - Adults older than 18 ; - Newly diagnosed with HFE hereditary haemochromatosis by genetic testing (homozygous for the C283Y mutation on HFE gene); - Treatment-naive; - Showing a ferritin level higher than 200µg/l for women and higher than 300µg/L for men; - Affiliated to French Social Security; - Having given a written informed consent. --- C283Y ---