SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report


Report for Clinical Trial NCT02833194

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

Assessment of the Prevalence of Major Psychiatric Disorders in a Cohort of Women With Clinical Criteria Corresponding to Pure, Abortive-form, Obstetrical, Antiphospholipid Syndrome

The primary objective of this study was to evaluate and compare the prevalence of the following psychiatric pathologies (based on the MINI5.0.0 questionnaire) among 3 groups of women (Leiden versus aP1Ab-positive versus thrombophilia-negative) with similar obstetrical histories 10 years after their initial assessment/diagnosis. - Mood disorders, including depressive episodes during the previous two weeks, recurrent depressive disorders at any point in life, dysthymia in the last two years, or any current or past manic episode; - Anxiety disorders, including current agoraphobia, current panic disorders, agoraphobia with panic disorders, current social phobia, generalized anxiety in the last 6 months, or current posttraumatic stress syndrome; - Apparent psychotic syndromes, including isolated or recurrent psychotic syndromes, past or present (clinically validated), - Current alcohol or drug problems (dependence or abuse).

NCT02833194 Antiphospholipid Syndrome Factor V Leiden Thrombophilia
MeSH: Syndrome Mental Disorders Problem Behavior Antiphospholipid Syndrome Thrombophilia Activated Protein C Resistance
HPO: Behavioral abnormality Hypercoagulability Resistance to activated protein C


Primary Outcomes

Measure: Mini Internationl Neuropsychiatric Interview 5.0.0

Time: 10 years

Time Perspective: Prospective

Cohort


There is one SNP

SNPs


1 V617F

Exclusion Criteria: - Any history of thrombotic events or any treatment given during previous pregnancies that might have modified the natural course of the condition - Women whose pregnancy losses could be explained by infectious, metabolic, anatomic or hormonal facotrs, or associated with paternal or maternal chromosomal causes - Seropositivity for HIV, hepatitis B or C - Women with antithrombin, protein C, or protein S deficiency, and women with abnormal fibrinogen or with the JAK2 V617F mutation were further excluded. --- V617F ---



HPO Nodes


HPO:
Behavioral abnormality
Genes 1262
NHLRC1 GPHN TACO1 UBA5 CLN8 NAT8L AARS ABAT GLRX5 ERBB4 ERCC2 MAK DGCR6 AMER1 ERCC3 ABCA4 ERCC4 ERCC5 ERCC6 PIGP ESS2 RNF168 ERF MANBA MAOA ACADL STUB1 ACADS ACAT1 SIGMAR1 MAPT CWC27 USP9X SLC35C1 KDM5C CDHR1 SMC1A ACOX1 MAX RPS6KA3 BCKDK TBC1D7 APC2 TMEM216 ACTB SLC6A19 MC1R LRRK2 MC4R NAA10 CHST6 ACTG1 L2HGDH DHDDS IKZF1 RPS20 PDZD7 RPS23 ADGRV1 ACY1 MDH2 RREB1 EZH2 COLQ ADAR ABCA7 MECP2 KLRC4 ADCY5 SLITRK1 WARS2 MEF2C MEFV GATAD2B MEIS2 MYORG TBC1D24 WAC SPG21 MEN1 FANCE SHROOM4 ARL6 ACSL4 TTC8 BPTF TUBB3 ARID1B MGAT2 SAG PANK2 FBP1 SARS NLGN4X ADSL MBTPS2 AARS2 CEP78 ATXN1 ATXN2 FKTN ATXN7 ATXN8OS FAM161A AGA HECW2 SCN1A SCN1B PCDH19 SCN2A RNASEH2C SCN3A POC1B MITF SCN8A AHCY ATXN3 SCN9A DCAF17 KIAA1109 AHR MLH1 AHSG FGD1 PRCD CC2D2A ANTXR1 KMT2A FGF8 PLA2G6 AKT1 FGF12 ALAD FGF14 FGFR1 TOMM40 FGFR3 ABCD1 FGFR2 HAX1 PWAR1 MERTK FH ALDH3A2 DOCK6 POMK DHTKD1 KCNT1 SLC9A6 FOXG1 SEC23B MOG SDHA SDHB SDHC SDHD ALPL FOXE3 FOXC2 DUOXA2 FOXE1 CUL4B FLI1 MRE11 FLII AMT FLT4 FOXRED1 CIB2 FMO3 DEAF1 NAA15 ANG FMR1 AFF2 ANK3 NOP56 OFD1 SLC25A4 CISD2 RNASEH2A NACC1 PUF60 PPM1D SGSH SH3BP2 ANXA11 PEX3 TTI2 CEP290 AGPAT2 RNF135 IYD KCNAB2 ARFGEF2 TMEM138 IKBKG ELP1 AIRE KIAA1549 FUZ POMGNT1 ICK UQCC2 NLRP1 FBXO11 SLC39A4 ALS2 NPC2 SPG11 CNKSR2 MSH2 CHD7 ST3GAL3 ZSWIM6 POMT1 APOE SIM1 APP SKI AP3B1 PRPF8 PIGV FAS TMEM127 AQP2 WDR26 SLC1A2 SLC1A3 ZNF365 SLC7A14 SLC1A4 COA8 TDP2 SLC2A1 SLC2A3 ARCN1 ARSG PEX26 ARF1 CYFIP2 SLC3A1 TRAK1 DHX30 EPG5 SLC5A2 FAN1 MTFMT ARG1 SLC5A5 SLC6A1 SLC6A3 MST1 SLC6A8 PACS1 ATF6 SETD2 LIPT1 VAC14 ARL3 MLH3 NDUFAF4 RPIA NPHP3 PIEZO2 POLR3B ARSA SLC25A12 STS ATP6 DKK1 SLC12A3 FRA16E COX1 COX2 COX3 ARVCF KLF13 WDR11 SLC16A2 CTCF ASAH1 FARS2 SLC18A2 MTHFR SLC18A3 ASCL1 SLC20A2 SLC25A1 OTUD6B TP63 ASL JRK TBK1 ND1 SLC22A5 GNB5 VPS35 ND4 ASPA NAXD ND5 CXORF56 ASS1 ND6 CLDN16 TIMM50 ANKRD11 SMARCA2 SMARCB1 WNT10A FLCN SMARCC2 DNAJC5 TRNE FOXP1 TRNF FTL NDUFAF6 SMPD1 CEP152 MFSD8 TRNH TRNL1 RIMS1 TRNL2 NGLY1 SNAP25 RERE FUS TRNN COASY ATP1A1 TBR1 TRNQ SNCB AP4B1 TBC1D23 ATP1A3 TRNS1 SNCA TRNS2 C9ORF72 MBD5 TRNW STX16 ZBTB11 ATP2A2 MCTP2 PRDM16 SNRNP200 LMBRD1 SNRPN STAG2 MUSK UNC13A ATP5F1A MVK RAI1 SOD1 GABRA1 SON SORL1 MYT1L GABRB2 SOX2 GABRB3 SOX3 GABRD SNORD115-1 SPATA7 SOX5 GABRG2 CERKL ATP6V1A CTSF ZMYND11 B4GALNT1 EMC1 ATP7A ADAT3 SPAST ATP7B WWOX SPG7 WDR4 SPIB ATRX AUH AVP MYO7A ERAP1 MYO9A SPR AVPR2 MYOD1 DISC2 NEXMIF SEPTIN9 KIZ ADAM9 ZNF423 NADK2 GJB6 TTLL5 KIF1B IQSEC2 NAGA NAGLU HDAC8 ASH1L CPLX1 GATA4 GATM GBA PWRN1 BBS2 SPART GBE1 CDH23 NFASC NBN GCDH SRY BCKDHA BCKDHB SLC46A1 RGS9 GCH1 NDN NDP POGZ UROC1 NDUFA2 MCCC2 TNFRSF11A NDUFA4 PLXND1 OPN1MW NDUFA6 GCSH PDE10A PEX11B NDUFA9 NDUFA10 ZC4H2 SUCLA2 COQ2 BCR ADA2 BCS1L AHDC1 NFU1 NDUFS1 NDUFS2 CIC ST14 MMADHC NDUFS3 NDUFV1 NAGS HESX1 NDUFS4 FGF17 STAT4 NDUFS8 NDUFV2 STAT5B SYNGAP1 NOD2 SLC52A3 IFIH1 NEFH CDKL5 BMP2 PROM1 PPARGC1A BMP4 GJA5 NEK1 GJA8 NEK2 BMPR1A GJB1 GJB2 GK NEUROD2 KISS1R PNPLA6 STXBP1 GLA PER3 NDUFA12 PER2 BRAF SYNJ1 PMPCA ST3GAL5 SUOX KLHL7 REEP6 GLDC GLE1 NFIB SQSTM1 NFIX GLI3 ABCC8 SURF1 GLRA1 GLRB GLS EIF2B4 GLUD1 EIF2B3 AFG3L2 VAMP1 EIF2B2 EIF2B5 VPS13A SCAPER SYN1 SMG9 GM2A AP1S2 SYT1 PACS2 NHS SGCE GNA11 CACNA1H C4A CACNA1G TAC3 GNAI3 TACR3 GNAO1 GNAQ TAF1 GNAS SEMA4A HERC2 GNAT2 CAMTA1 GNB3 PHOX2B CLP1 GPT2 BRAT1 USP27X NONO GNRH1 KYNU GNRHR AP3D1 GNS TAT CFAP410 TBX1 ALG1 NOTCH3 AGTPBP1 CA4 GP1BB PNP TBP TBX2 NPC1 TLK2 NPHP1 CACNA1A NPM1 CACNA1C CACNA1D CACNA1F LIAS TCF4 HNF1A HNF1B CACNB4 SATB2 SLC25A20 CUX2 DNAJC13 TCF12 TCN2 NRL SZT2 GPR35 HCN1 NTRK1 NTRK2 DOK7 NUMA1 NUP88 HGSNAT NR4A2 SLC19A3 NSD1 BAZ1B GPR143 ARHGEF18 GRIA3 GRIA4 CASR GRN RTN4IP1 OCA2 GRIN1 GRIN2A GRIN2B OCRL SYT2 SPECC1L AIP GRIN2D RUNX2 NR3C1 MED13L SLC7A7 ADNP RAX2 ATP13A2 CBS TFAP2B CLDN10 OPA1 SIL1 ZFPM2 OPHN1 POLR3A GSS CRB1 KPTN TG CCNF IL1RAPL1 TGFBI UNC119 AP4E1 TGFBR2 TARDBP MSH6 USP8 TH WDR45 GTF2E2 OTC AP4S1 SLC35A3 KLLN OTX2 ERLIN2 GTF2I THRA THRB LINGO1 ATAD1 GUCA1A GUCA1B SMC3 PRPF4 P2RY11 NKX2-1 PRPF3 AIFM1 IL12A-AS1 TK2 TKT GYS2 CEP250 GUCY2D ENTPD1 TLR4 PAH SLC6A5 TREM2 CKAP2L PAK3 WDR73 ZFYVE26 SERAC1 HSD17B10 HADHA HAL AP4M1 HARS TNFRSF1A POLG2 SLC25A19 KAT6B HBB PC CDC42 PCCA PCCB AGRN HCCS TNXB SLC33A1 TNPO3 HCRT CDH15 MAN1B1 TP53 PCNA HTT PCNT XPR1 LARGE1 SLC24A5 VAPB HEXA PIGY PCSK1 TPO SDHAF1 TMEM67 PCYT1A LRAT TREX1 RAB11B SCN11A ARL2BP PNKP PDE4D HIVEP2 PDE6A HK1 PDE6C PGAP3 PDE6G PDE6H HLA-A TRHR HLA-B PDGFB TRIO MICOS13 PDE6B PDGFRB PDHA1 HLA-DQB1 AMACR HLA-DRB1 PARK7 SLC26A4 ELOVL5 SLC5A7 HLCS PEX1 PEX6 PEX10 HMBS PEX12 PEX13 PEX14 RNF13 CHAT HPSE2 TSC1 CHD1 TSC2 CHD2 HMGCL TSHB TSHR TSPYL1 AGBL5 PFN1 HNF4A TRIP12 ATXN8 LYST HNRNPA1 TUB HNRNPA2B1 PGK1 CHRNA2 CHRNA7 NLRC4 HNRNPH2 TULP1 HIRA TWIST1 TNFSF4 OVOL2 TYR TYROBP KMT2C ZDHHC15 RAB28 AP2S1 UBE2A CLCN2 CLCN4 NRXN1 NALCN PIGH CLCNKB UBE3A PIK3CA CLN3 HS6ST1 HPRT1 UCP2 UFD1 CLTC PITX3 NPAP1 CIZ1 FBXO7 PEX16 HRAS ASPM FSCN2 AIPL1 GTF2H5 DNAJC12 RNF216 CCR1 PLCB4 PLCD1 ATXN10 DGCR8 PLEC TMCO1 ITM2B USH2A ALG6 CLRN1 CNGB1 CNGA1 KDM6A NIPBL CNGA3 ALG12 COG4 PUS7 VCP PML COL1A1 PMM2 VDR COL1A2 COL2A1 PMP22 VEGFC COL3A1 POMT2 PMS1 PROK2 VHL WHRN COL5A1 HSPG2 NDUFB11 NDST1 VLDLR PIGL BEST1 PSAT1 PMS2 VRK1 COL11A2 MAGEL2 TBX4 COL13A1 UBQLN2 COL17A1 NDUFAF5 COMT ARV1 NMNAT1 ADAMTS2 CLIP2 MBOAT7 FKRP WFS1 POLA1 INPP5E FA2H RRM2B POLG POLH NDUFAF3 POMC PON1 COX7B PON2 PON3 COX10 POU1F1 DUOX2 POU2AF1 COX15 CP TWNK XK TSEN54 SAMHD1 DRAM2 XPA XPC SIN3A CPOX NABP1 IDH3B CPS1 CPT1A IDS GABBR2 GTF2IRD1 IDUA CREBBP YWHAG PREPL SHANK3 SH2B1 CRKL NECAP1 CHMP2B PPOX CRX TMEM106B PPP2CA CRYGC PPP2R2B CACNA2D4 IGF1 BCL11B IGF1R PPP3CA SNCAIP MMEL1 NSMF CSF1R KANSL1 SEC24C CYP2R1 PPT1 CSNK1D PRF1 CSNK2A1 RGS9BP NUS1 C12ORF65 SETBP1 CNGB3 RBPJ PRKACA CNTNAP2 PITPNM3 AUTS2 MPLKIP PRKAR1A PRKAR1B NKX2-5 GIGYF2 SLC13A5 PRKCG DEPDC5 CTNS MAPK1 CTNNB1 SLC45A1 MAPK10 GFM1 CEP57 CTSH PRNP TMEM240 PRODH PROP1 PINK1 SEMA3E ZNF513 ATPAF2 PRPH PRPS1 MKRN3 IL10 IL12A PRPF31 IL12RB1 IFT140 IBA57 CHCHD10 CNNM2 AHI1 NDUFS7 DYM ZBTB16 ZBTB20 IMPA1 PSAP FRMPD4 IMPDH1 HDAC4 PSEN1 PSEN2 NDE1 TMEM237 ABCA12 PET100 CYP11B1 IFT172 KCNV2 CYP11B2 SLC6A17 MATR3 CYP27A1 DHX38 RNF113A CYP27B1 IPW DAO FTSJ1 CC2D1A PTPN22 IRF5 TUBB2B PRPF6 DBH UPF3B PSMD12 NHLRC2 MCCC1 DBT GPR101 PTEN BCOR MFRP DNAJC6 NPHP4 DCTN1 NSUN2 DDB2 DDC ITGB6 ZEB2 PHGDH SNORD116-1 DDX3X TTC19 ITPA ITPR1 RUSC2 NSDHL DDX11 LRIG2 TIMM8A ANOS1 PRDM8 EFHC1 KCNA2 RNF125 ALMS1 KCNB1 PROKR2 TINF2 SDHAF2 SACS FIG4 PAX8 CCDC47 PTS KCNJ1 USH1G KCNJ2 KCNJ5 CABP4 DGUOK DHCR7 C19ORF12 KCNJ10 KCNJ11 TMEM70 KCNJ13 ARNT2 PEX19 PCDH15 PEX2 PEX5 CLN6 MFN2 KIF14 ALDH18A1 DLAT KCNQ2 FIP1L1 DLD KCNQ3 DLG3 CDC73 SLC52A2 SARDH TMEM231 DNM1 DMPK DNA2 QDPR KISS1 ALDH5A1 TNFSF15 PHIP MED12 IL23R WDR62 RAC1 KIF11 DNMT1 KNL1 IMPG2 PDE11A RAD21 RNASEH2B KRAS DPAGT1 SLC12A6 RPGRIP1 DGCR2 KRT3 DPP6 DPYD C12ORF4 DPYS NR2E3 KRT12 DRD2 EPM2A RAPSN RARA RARS LHX4 GNE NDUFAF2 SOBP RBBP8 KRT81 KRT83 KRT86 DUSP6 RBP3 DYRK1A OPN1LW TOR1A RDH5 LAMB1 RDH12 LAMB2 PRPH2 DNM1L ALG11 GJC2 PCARE LHX3 DPF2 RET REV3L PRRT2 RFC2 ECE1 USH1C PQBP1 ECHS1 ECM1 COL4A3BP TBL1XR1 MCOLN1 RGR MTPAP JMJD1C LEP LEPR EDN1 MSTO1 RSPRY1 NLRP3 KCTD17 RHO MKRN3-AS1 EEF1A2 RLBP1 PIKFYVE LHCGR NDUFA13 LHX1 CNNM4 LINS1 MLXIPL LIG4 SNX14 LRPPRC LIMK1 EYS SEPSECS OPTN BCAP31 EGF LMNB1 IFT88 RDH11 KMT5B SETD5 ZDHHC9 ATAD3A AASS VANGL1 EIF2B1 ATP6AP2 EIF2S3 ARID2 ZNF408 SLC25A15 ARMC5 AP3B2 SPRY4 HPS6 SYT14 RLIM EIF4G1 EHMT1 SASS6 SPRED1 TRPV4 UBAC2 ROM1 SLC45A2 RORA ELP2 ALG3 DSG4 BSCL2 RP9 TAF15 LTBP2 RP1 ELN LTBP3 RP2 RPGR EML1 C8ORF37 TANGO2 MAP11 LAS1L TOPORS LRMDA TACSTD2 EPCAM RPE65 VPS53 TBL2 CD96 EP300 CRBN RPL10 SMAD4 JPH3 EPHA4 ALG13
Hypercoagulability
Genes 17
GATA2 AGGF1 MYD88 F5 HRG DLD F9 PLAT THBD SPTA1 EPB42 SPTB PROC SLC4A1 PROS1 PIGA ANK1
Resistance to activated protein C
Genes 1
F5