SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report


Report for Clinical Trial NCT03612908

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

TSHβX1 Splice Variant Expression and D2 Thr92Ala Polymorphism Analysis in Pregnant Women With Thyroid Diseases

Thyroid diseases are pathologies that frequently affect pregnant women causing serious complications. This current research aims to find out whether the expression of TSHβX1 splice variant and D2 Thr92Ala polymorphism in the DIO2 gene are associated with thyroid disease in Mexican pregnant women.

NCT03612908 Pregnancy Related Hypothyroidism Hyperthyroidism
MeSH: Hypothyroidism Hyperthyroidism
HPO: Hyperthyroidism Hypothyroidism


Primary Outcomes

Description: Frequency of positive cases for the TSHβX1 splice variant identified by real-time polymerase change reaction.

Measure: TSHβX1 splice variant expression.

Time: Baseline.

Secondary Outcomes

Description: Allele frequency identification of the D2 Thr92Ala polymorphism by genotyping method.

Measure: D2 Thr92Ala polymorphism.

Time: Baseline.

Time Perspective: Prospective

Case-Control


There is one SNP

SNPs


1 T92A

TSHβX1 Splice Variant Expression and D2 Thr92Ala Polymorphism Analysis in Pregnant Women With Thyroid Diseases. --- Thr92Ala ---

TSHβX1 and D2 THR92ALA in Pregnancy Thyroid diseases are pathologies that frequently affect pregnant women causing serious complications. --- THR92ALA ---

This current research aims to find out whether the expression of TSHβX1 splice variant and D2 Thr92Ala polymorphism in the DIO2 gene are associated with thyroid disease in Mexican pregnant women. --- Thr92Ala ---

TSHβX1 splice variant expression.. Frequency of positive cases for the TSHβX1 splice variant identified by real-time polymerase change reaction.. D2 Thr92Ala polymorphism.. Allele frequency identification of the D2 Thr92Ala polymorphism by genotyping method.. Inclusion Criteria: - Pregnant women attended at the "Mónica Pretelini Sáenz" Maternal-Perinatal Hospital (HMPMPS), Health Institute of the State of Mexico (ISEM), Toluca, Mexico. --- Thr92Ala ---

TSHβX1 splice variant expression.. Frequency of positive cases for the TSHβX1 splice variant identified by real-time polymerase change reaction.. D2 Thr92Ala polymorphism.. Allele frequency identification of the D2 Thr92Ala polymorphism by genotyping method.. Inclusion Criteria: - Pregnant women attended at the "Mónica Pretelini Sáenz" Maternal-Perinatal Hospital (HMPMPS), Health Institute of the State of Mexico (ISEM), Toluca, Mexico. --- Thr92Ala --- --- Thr92Ala ---



HPO Nodes


HPO:
Hyperthyroidism
Genes 46
CDH23 CACNA1S TWNK TRNF AKT1 TRNH TSHR TRNL1 GNAS KCNJ18 TRNQ THRB TRNS1 TRNS2 RREB1 SLC12A3 COMT SEC24C POLG2 COX1 PTEN COX2 COX3 TRNW SLC25A4 CLCNKB ARVCF SUGCT PIK3CA JMJD1C MSTO1 HLA-DRB1 TBX1 RRM2B POLG BTNL2 ND1 POLR3A UFD1 ND4 HIRA GABRA3 GP1BB ND5 ND6 FOXP3
Hypothyroidism
Genes 235
PCSK1 SOX3 GABRD TPO UBR1 TMEM67 TREX1 PDE4D ZBTB20 PLVAP TRH STUB1 WDR4 TRHR MCM8 DNAJC19 MARS ENPP1 HLA-DRB1 PIEZO1 SLC26A4 ACP5 IQSEC2 GAS1 MC2R GATA1 GATA6 CDH23 SRY TSC1 TSC2 GCH1 EXT2 TSHB TSHR PTCH1 RREB1 PTEN BCOR ADA HNF4A ADAR TRIP13 ALX4 DDOST STAR HESX1 STAT1 PHF21A STAT3 TBC1D24 HIRA MEN1 IFIH1 DACT1 BMP4 SAA1 ARL6IP6 KISS1R SALL1 ALMS1 BRAF PROKR2 CLPB PIK3C2A PAX8 HPD PIK3CA FDX2 SGPL1 GLI2 GLI3 KCNJ10 RNASEH2C SCN4A UFD1 BUB1 ARNT2 BUB1B DCAF17 C1QBP ALG8 FGF8 AKT1 KIAA0556 FGFR1 GNAS HSD17B3 FOXH1 NODAL EIF2AK3 KDM6A TRAPPC9 TBX1 CDON FOXI1 GP1BB PMM2 FOXP3 DUOXA2 FOXE1 NPHS1 RNASEH2B CACNA1C RAG1 RAG2 FLII HNF1B DMXL2 FBLN5 ADAMTSL1 B3GLCT DEAF1 FMR1 LHX4 COMT SLC25A4 GNE CLIP2 RNASEH2A WFS1 RRM2B POLG EFEMP2 IYD KCNAB2 GLIS3 POMC APC SHH AIRE BAZ1B POU1F1 DUOX2 DNM1L CP TWNK POU3F4 SAMHD1 CHD7 TDGF1 LHX3 AIP TXNRD2 RBM28 APOE RFC2 XRCC4 SIX3 GTF2IRD1 SKI DLL1 TF EXOSC2 JMJD1C ABCC6 LEP OPA1 LEPR ZIC2 DNAH1 TG SLC5A5 RMRP GPR161 LIFR TGIF1 MLXIPL LIG4 LIMK1 KMT2D OTX2 GTF2I THRA THRB SEC24C COX1 COX2 COX3 ARVCF WDR11 DCLRE1C SLC16A2 NKX2-1 FANCI BTNL2 PPP1R15B MRAP ND1 SETBP1 ND4 ND5 ND6 PTRH2 PRKAR1A LRP4 FLCN STEAP3 NKX2-5 ROBO1 TRNF TRNH FUCA1 ELN TRNL1 TRNL2 RERE CTNS TRNN LRBA CTNNB1 IGSF1 TRNQ TANGO2 TRNS1 TRNS2 BUB3 POLG2 FUT8 TRNW KAT6B HBB SUFU CEP57 IL2RA PRDM16 IL2RG NNT TBL2 DISP1 RAI1 IL7R PROP1 SEMA3E NIN