SNPMiner Trials by Shray Alag


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Report for Clinical Trial NCT03209063

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

The Role of Prothrombin Gene Polymorphism as a Risk Factor for Recurrent Pregnancy Loss

Recurrent miscarriage is a pregnancy loss before 20 weeks of gestation. The recurrent pregnancy loss usually occurring in the first trimester of gestation and its rate is quite high (15-20% even in full reproductive period) . In 2012, the American Society for Reproductive Medicine Practice Committee issued a statement that defined recurrent pregnancy loss as a disease distinct from infertility defined by two or more failed consecutive pregnancies.

NCT03209063 Recurrent Pregnancy Loss
MeSH: Abortion, Spontaneous Fetal Death Abortion, Habitual
HPO: Spontaneous abortion Stillbirth

1 Interventions

Name: polymerase chain reaction

Description: diagnostic test as Polymerase chain reaction for detection of Prothrombin gene mutation

Type: Diagnostic Test

Group 1 Group 2 Group 3


Primary Outcomes

Description: using polymerase chain reaction Polymerase chain reaction

Measure: percentage of recurrent pregnancy loss with the presence of prothrombin gene mutation in these women

Time: 2 days

Time Perspective: Prospective

Case-Control


There are 3 SNPs

SNPs


1 A1298C

Thrombophilia was identified as a major cause of recurrent pregnancy loss , Because pregnancy is a hypercoagulable state, thromboembolism is the leading cause of antepartum and postpartum maternal mortality .The four most common genetic markers for thrombophilia are; prothrombin gene mutation(FII, G20210A), methylene tetra hydrofolate reductase mutations (MTHFR and A1298C), factor V Leiden (FVL, G1691A) , and plasminogen activator inhibitor 1 (PAI-1) . --- G20210A --- --- A1298C ---


2 G1691A

Thrombophilia was identified as a major cause of recurrent pregnancy loss , Because pregnancy is a hypercoagulable state, thromboembolism is the leading cause of antepartum and postpartum maternal mortality .The four most common genetic markers for thrombophilia are; prothrombin gene mutation(FII, G20210A), methylene tetra hydrofolate reductase mutations (MTHFR and A1298C), factor V Leiden (FVL, G1691A) , and plasminogen activator inhibitor 1 (PAI-1) . --- G20210A --- --- A1298C --- --- G1691A ---


3 G20210A

Thrombophilia was identified as a major cause of recurrent pregnancy loss , Because pregnancy is a hypercoagulable state, thromboembolism is the leading cause of antepartum and postpartum maternal mortality .The four most common genetic markers for thrombophilia are; prothrombin gene mutation(FII, G20210A), methylene tetra hydrofolate reductase mutations (MTHFR and A1298C), factor V Leiden (FVL, G1691A) , and plasminogen activator inhibitor 1 (PAI-1) . --- G20210A ---

Prothrombin G20210A refers to a human gene mutation that increases the risk of blood clots.The variant causes elevated plasma prothrombin levels (hyperprothrombinemia), Prothrombin is the precursor to thrombin, which plays a key role in causing blood to clot (blood coagulation).Prothrombin G20210A can thus contribute to a state of hypercoagulability . --- G20210A ---

Prothrombin G20210A refers to a human gene mutation that increases the risk of blood clots.The variant causes elevated plasma prothrombin levels (hyperprothrombinemia), Prothrombin is the precursor to thrombin, which plays a key role in causing blood to clot (blood coagulation).Prothrombin G20210A can thus contribute to a state of hypercoagulability . --- G20210A --- --- G20210A ---



HPO Nodes


HPO:
Spontaneous abortion
Genes 21
MGP MPL GPHN FGA MTMR14 FGB JAK2 HOXA13 MYF6 SERPINC1 SYCP3 XIST BIN1 F13A1 F13B RYR1 HTR1A DNM2 FGG THPO WRN
Stillbirth
Genes 23
COL2A1 ESCO2 LMNA SLC35D1 OSTM1 GBA CENPF HYLS1 GDF5 TRIP11 SLC26A2 FLNA FLNB MUSK PTH1R NEK8 PHGDH COL11A1 ALPL LBR RNU4ATAC ZMPSTE24 NSDHL