SNPMiner Trials: Clinical Trial Report
Report for Clinical Trial NCT00579683
Developed by Shray Alag, 2019.
SNP Clinical Trial Gene
The purpose of this study is to try to learn more about how small molecule kinase inhibitors
work in treating lung cancer. Some early studies have shown that gefitinib, erlotinib and
similar drugs are more likely to work if a particular DNA change (also known as a mutation)
is found in a protein that is important in lung cancer. This protein is called the epidermal
growth factor receptor (EGFR). Since small molecule kinase inhibitors sometimes stop working,
we would like to examine your tumor to learn why these medicines are not working as well.
Your tumor will be examined for a variety of things including changes in the DNA of the EGFR.
We will also sequence parts of the genes for HER2, HER3, HER4, and KRAS, other proteins
thought to be important in lung cancer.
Name: Tumor core biopsy for RNA isolation
Description: RNA isolation will be carried out using approximately 25 mg of gross tissue from these tumor specimens.Type: Other
1
Primary Outcomes
Measure: To compare EGFR gene sequence in patients upon relapse with EGFR gene sequence prior to treatment with small molecule kinase inhibitors.
Time: 2 years
Secondary Outcomes
Measure: To identify novel mutations in the tyrosine kinase domain of EGFR in patients with acquired resistance to small molecule kinase inhibitors.
Time: 2 years
Measure: To more precisely characterize the frequency and clinical implications of T790M in patients with acquired resistance to small molecule kinase inhibitors.
Time: 2 years
Measure: To identify novel mechanisms of acquired resistance to EGFR small molecule kinase inhibitors.
Time: 2 years
Time Perspective: Prospective
Case-Only
There is one SNP
SNPs
1 T790M
To more precisely characterize the frequency and clinical implications of T790M in patients with acquired resistance to small molecule kinase inhibitors.. null. --- T790M ---
HPO Nodes
HPO:Neoplasm of the lung
Genes 43
WT1 KRAS SLC22A18 STK11 IRF1 AKT1 C11ORF95 PRKN PPP2R1B ERBB2 TRPV3 TSC1 POU6F2 TSC2 EWSR1 RELA KEAP1 REST DIS3L2 SFTPA2 GPC3 MBTPS2 LMNA PTEN BRAF BRCA2 EGFR RB1 TRIP13 PDGFRB TERT SFTPC PIK3CA TRIM28 DICER1 MAP3K8 HPGD SLCO2A1 H19 TP53 NOTCH3 BAP1 WRN hr>Non-small cell lung carcinoma
Genes 2
TP53 BAP1 hr>