The aim of this study was to determine the kinetics of perioperative circulating DNA in three types of cancer. This first step will enable further studies comparing the potential impact of certain techniques or anesthetic products on cancer surgery.
Name: Blood test
Description: plasma concentration of circulating DNA of specific genesType: Othercirculating DNA plasma level test
Description: ng/mL in plasma
Measure: Change in concentration of total mutant circulating DNA Time: Nine timepoints between Day-1 to Day 3Description: ng/mL in plasma
Measure: Change in proportion of mutant circulating DNA Time: Nine timepoints between Day-1 to Day 3Description: concentration of long ACTB ctDNA fragments/concentration of short ACTB ctDNA fragments
Measure: Change in integrity index of circulating DNA for ACTB gene Time: Nine timepoints between Day-1 to Day 3Description: concentration of long KRAS ctDNA fragments/concentration of short KRAS ctDNA fragments
Measure: Change in integrity index of circulating DNA for KRAS gene Time: Nine timepoints between Day-1 to Day 3Description: ng/mL in plasma
Measure: Change in plasma concentration of long (~ 290bp) fragments of ACTB gene Time: Nine timepoints between Day-1 to Day 3Description: ng/mL in plasma
Measure: Change in plasma concentration of short (~ 145bp) fragments of KRAS gene Time: Nine timepoints between Day-1 to Day 3Description: ng/mL in plasma
Measure: Change in plasma concentration of long (~ 300bp) fragments of KRAS gene Time: Nine timepoints between Day-1 to Day 3Description: ng/mL in plasma
Measure: Change in plasma concentration of mutant KRAS DNA fragments Time: Nine timepoints between Day-1 to Day 3Description: ng/mL in plasma
Measure: Change in plasma concentration of BRAF DNA fragments with V600E mutation Time: Nine timepoints between Day-1 to Day 3Case-Only
There is one SNP
Change in plasma concentration of BRAF DNA fragments with V600E mutation. --- V600E ---