The GEOLynch cohort study has been established to investigate the influence of genetic, environmental and other factors on tumour risk in persons with Lynch syndrome.
Name: No intervention, observational study.
Type: OtherPersons with Lynch syndrome
Description: All diagnosed colorectal adenomas and carcinomas described in paticipants' medical reports and/or pathology reports.
Measure: Colorectal tumour diagnoses Time: Diagnoses before and after study inclusion will be assessed approximately every 2 years until study completion by regularly reviewing medical reports and/or pathology reports.Description: All diagnosed endometrial cancers described in participants' medical reports and/or pathology reports.
Measure: Endometrial cancer diagnoses Time: Diagnoses before and after study inclusion will be assessed approximately every 2 years until study completion by regularly reviewing medical reports and/or pathology reports.Description: All diagnosed cancer types described in participants' medical reports and/or pathology reports.
Measure: Overall cancer diagnoses Time: Diagnoses before and after study inclusion will be assessed approximately every 2 years until study completion by regularly reviewing medical reports and/or pathology reports.Cohort
There is one SNP
DNA has been subtracted from the buccal swabs to genotype SNPs of the IGF gene axis and polymorphisms of MTHFR C377T. --- C377T ---