SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report


Report for Clinical Trial NCT01670396

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

G Protein β3 Subunit (GNB3) Polymorphism and Restenosis of Coronary Drug-eluting Stents

The investigators hypothesized that genetic variants of G protein influence the development of restenosis and clinical outcome of patients receiving drug-eluting stents (DES).

NCT01670396 Coronary Artery Disease
MeSH: Coronary Artery Disease Myocardial Ischemia Coronary Disease
HPO: Coronary artery atherosclerosis


Primary Outcomes

Measure: In-stent restenosis

Time: 6-24months after stent implanting

Secondary Outcomes

Measure: target lesion revascularization (TLR)

Time: 6-24months after stent implanting

Measure: re-myocardial infarction

Time: 6-24months after stent implating

Time Perspective: Retrospective

Case Control


There is one SNP

SNPs


1 C825T

The initial and subsequent studies suggest that the T allele of C825T polymorphism is associated with enhanced transmembrane signaling via Gi proteins. --- C825T ---



HPO Nodes


HPO:
Coronary artery atherosclerosis
Genes 34
TGFB2 TGFB3 TGFBR1 LDLRAP1 TGFBR2 MFAP5 APOA1 APOB ABCA1 MYH11 ELN LIPC FBN1 PRKG1 APOE PPARG ZMPSTE24 MYLK LMNA CYP7A1 SERPIND1 LDLR LOX MAT2A ABCG5 ABCG8 KCNJ5 ESR1 ZNF687 SMAD3 PCSK9 CEP19 ACTA2 FOXE3