The genotype profile of CYP2C8 was analyzed in a Korean population. Frequency in multi-ethnic population and in vivo functionality of novel null allelic CYP2C8 variant were evaluated.
Name: Rosiglitazone
Description: single oral administration of 4mg of rosiglitazoneType: Drugrosiglitazone genetic polymorphism
Name: CYP2C8 genotype
Description: CYP2C8*11.Type: Geneticrosiglitazone genetic polymorphism
Description: 0h,0.33h,0.66h,1h,1.5h,2h,3h,4h,6h,8h,12h,24h
Measure: AUC Time: 12hrDescription: 0h,0.33h,0.66h,1h,1.5h,2h,3h,4h,6h,8h,12h,24h
Measure: Cmax Time: 12hrAllocation: Non-Randomized
Parallel Assignment
There is one SNP
The Effect of CYP2C8 E274Q, a Novel 23452 G>T SNP, on the Disposition of Rosiglitazone in Healthy Subjects: The Genetic Polymorphisms of CYP2C8 in a Korean Population. --- E274Q ---