The investigators hypothesize that genes that play a role in menstrual migraine can be identified using a well characterised migraine population and a comprehensive genome-wide association scan approach. The aim of the study is to identify genes, genetic regions, and the effect of hormones on expression profiles in women with menstrual migraine compared to a control population with no personal or first-degree family history of migraine. In this case control study, saliva samples will be taken from 300 cases and 300 controls for DNA analysis. Blood samples from 30 cases and 30 controls will be taken during the follicular phase as well as the luteal phase of the menstrual cycle for ribonucleic acid (RNA) analysis.
Description: PR PROGINS
Measure: Progesterone Receptor Gene Polymorphism PROGINS in Women With Menstrual Migraine and Women Without Migraine Time: 6 yearsDescription: ESR1 G594A
Measure: Estrogen Receptor 1 G594a Polymorphism in Women With Menstrual Migraine and Women Without Migraine Time: 6 yearsDescription: ESR1 C325G
Measure: Estrogen Receptor 1 C325G Polymorphism in Women With Menstrual Migraine and Women Without Migraine Time: 6 yearsDescription: PgR and ESR
Measure: Menstrual Cycle Expression of PGR and ESR in Women With Menstrual Migraine and Women Without Migraine Time: 6 yearsDescription: TNF
Measure: Tumour Necrosis Factor Genotype in Women With Menstrual Migraine and Women Without Migraine Time: 6 yearsDescription: SYNE1
Measure: SYNE1 Genotype in Women With Menstrual Migraine and Women Without Migraine Time: 6 yearsDescription: TNF and SYNE1
Measure: Menstrual Cycle Expression of TNF and SYNE1 in Women With Menstrual Migraine and Women Without Migraine Time: 6 yearsCase Control
There are 2 SNPs
Estrogen Receptor 1 C325G Polymorphism in Women With Menstrual Migraine and Women Without Migraine. --- C325G ---
ESR1 C325G. --- C325G ---
ESR1 G594A. --- G594A ---