SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report


Report for Clinical Trial NCT02725333

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

Does Shoulder Stabilizations Stabilize Shoulders?

Background: There is no evidence that shoulder stabilization effectively corrects the glenohumeral translation in unstable shoulders, explaining residual apprehension in certain patients. The purpose of this study was to analyze the effect of surgical stabilization on glenohumeral translation. Methods: Anteroposterior and superoinferior translations were assessed in patients, before and after shoulder stabilization, through a dedicated patient-specific measurement technique based on optical motion capture and computed tomography.

NCT02725333 Shoulder Dislocation Shoulder Pain Joint Instability Syndrome
MeSH: Shoulder Pain Joint Dislocations Shoulder Dislocation Joint Instability
HPO: Joint dislocation Joint laxity Shoulder dislocation Shoulder pain

1 Interventions

Name: Shoulder Stabilization

Description: Open Latarjet was performed as the standard and well-described Latarjet-Patte procedure with subscapularis split and triple locking mechanism.14 The graft was intra-articular in every case, the capsule was systematically reattached to glenoid according to Favard's modification,15 and a capsular shift was added. Arthroscopic Latarjet was carried out in one case according to a modified Lafosse technique.16 In the latter treatment option, no reattachment of the capsule was realized. The arthroscopic Bankart repair consisted in a mobilization of the anteroinferior capsule and the labrum with an arthroscopic elevator. The glenoid rim and neck were then prepared with a mechanical shaver device. Two loaded anchors were inserted at the 5 and 3 o'clock position, and sutures were shuttled across the inferior glenohumeral ligament and labrum, starting at the inferior position and progressing in a superior direction.

Type: Procedure

Shoulder Stabilization


Primary Outcomes

Description: Percentage of glenohumeral translation.

Measure: Comparison of ipsilateral glenohumeral translation (unstable side) pre- and postoperatively.

Time: 1 year

Description: Percentage of glenohumeral translation

Measure: Comparison of glenohumeral translation between ipsilateral side (unstable side) and contralateral (stable) side.

Time: 1 year

Secondary Outcomes

Measure: Prevalence of postoperative apprehension, new dislocation or subluxation in relation to the main outcomes of interest.

Time: 1 year

Description: Comparison of glenohumeral range of motion pre-postoperatively

Measure: Range of motion

Time: 1 year

Other Outcomes

Description: Baseline characteristics

Measure: Age, sex, shoulder side, and limb dominance

Time: 1 year

Purpose: Diagnostic

Single Group Assignment


There is one SNP

SNPs


1 T40S

Kinematic data was recorded using a Vicon MX T-Series motion capture system (Vicon, Oxford Metrics, UK) consisting of twenty-four cameras (24 × T40S) sampling at 120 Hz. --- T40S ---



HPO Nodes


HPO:
Joint dislocation
Genes 312
TPM2 TPM3 MKKS GPHN HFE SOX9 GDF5 SOX11 HGD ATP6V1A TCTN3 MYH3 ASXL1 AARS MASP1 ATP6V1E1 MYH7 CCDC8 MYH8 ERCC1 ERCC2 B4GALT7 SF3B4 ERCC3 BRIP1 ERCC4 DYM NOG MYL2 ATP7A ZMPSTE24 ATR MAP1B CHST14 MYO9A SCARF2 ORC6 USP9X EIF4A3 CFL2 SMC1A INPP5K CYP27A1 APC2 RNF113A ACTA1 TRPS1 HDAC8 CPLX1 MAP3K20 SLC5A7 DNAJC21 FGFRL1 CHAT PTPN22 GCDH EXT1 KLHL41 EXT2 EXTL3 EYA1 CUL7 SSR4 SMOC1 ITGA7 NEB RREB1 C12ORF57 PTEN ARID1A ZC4H2 SLC10A7 CHRM3 CHRNA1 NLRC4 B3GAT3 RYR1 STAT4 CHRND BGN CHRNG HIRA RNU4ATAC CDC45 NSDHL FANCA FANCC FANCD2 FANCE PHEX XYLT1 SHROOM4 SLC2A10 HOXA11 IFIH1 BMP1 GJA1 FANCB PTPN2 FANCF COLEC11 FANCG IFITM5 IMPAD1 LONP1 ZNF469 ARID1B FBN1 FBN2 GPC3 BRCA1 MBTPS2 TMTC3 CLCN7 BRCA2 AEBP1 CANT1 KLHL7 FIG4 GLI3 DSTYK DHCR7 GLRA1 GLRB RECQL4 GORAB UFD1 HACE1 ARNT2 DHODH PITX1 VAMP1 GPC4 GTF2H5 PYCR1 ALDH18A1 KMT2A AKT1 ECEL1 RBM8A FGFR3 CDT1 MAD2L2 DMPK FHL1 GMPPB MAP3K7 PLOD1 EIF2AK3 KDM6A NIPBL DNASE1L3 TBX1 NOTCH2 KIF22 GP1BB CHST3 COL1A1 RAD21 VDR COL1A2 COL2A1 RAD51 COL3A1 RAD51C TBX15 POMT2 BICD2 COL5A1 FLI1 COL5A2 COL6A1 HSPG2 COL6A2 FLNA COL6A3 FLNB PIGL RAP1A RAP1B COL12A1 TBX4 COL13A1 DONSON COMP NEDD4L COMT OFD1 ADAMTS2 CLIP2 FKRP PUF60 WHCR SLC26A2 NSD2 WNT5A COL27A1 WNT7A SMARCAL1 GNPTAB UBE3B ROR2 DVL1 DVL3 EXOSC3 OBSL1 APC ARFGEF2 NSD1 BAZ1B PORCN B3GALT6 SHOX FANCL CHST11 COLEC10 OCRL SYT2 POMT1 DPF2 OSGEP XRCC2 RFC2 SIX1 FANCM GTF2IRD1 SKI GPC6 SELENON NXN GSC CREBBP ANKRD55 YWHAE ANKH GMNN SLC40A1 JMJD1C PALB2 LETM1 NLRP3 SIL1 ARF1 RFWD3 KIF7 ORC1 TGFBR1 ORC4 SLC6A9 TGFBR2 LMOD3 LIMK1 SETD2 GTF2E2 VAC14 IARS2 SLC35A3 KMT2D CD247 PIEZO2 PPP2R5D GTF2I THRA KANSL1 SEC24C LMNA ATAD1 UBE2T ARVCF SMC3 SETD5 LMX1B SLC18A3 FANCI SLC25A1 ARID2 ALG9 PAFAH1B1 EBP TGDS SLC6A5 PTRH2 SMARCA2 GEMIN4 MPLKIP PRKAR1A SMARCA4 LRP4 SMARCB1 SMARCC2 SMARCE1 CTBP1 ELN SNAP25 CDC6 FUT8 KAT6B ERMARD SNRPB FZD2 IL2RA IL2RB MCTP2 AGRN TNXB HACD1 TBL2 CD96 EP300 SLX4 ATP6V0A2 LARGE1
Joint laxity
Genes 143
TPM2 CUL4B TPM3 DPAGT1 UBR1 FKBP10 MRE11 COL6A1 TCTN3 COL6A2 COL6A3 FLNB C12ORF4 FAT4 ATP6V1E1 NPR2 FBLN5 B4GALT7 EED COL12A1 B3GLCT COL13A1 MYL2 ATP7A PIGP FMR1 GALNS COMP DCPS CHST14 ADAMTS2 CLIP2 MYO9A PUF60 SOBP USP9X IARS TMEM165 TENT5A PIGS SERPINF1 ACTA1 GATA1 MAP3K20 SLC5A7 NSD1 BAZ1B FARSB PORCN B3GALT6 CHAT SIN3A POGZ SYT2 RET RFC2 SRCAP ITGA7 GTF2IRD1 SKI ADNP CBL SHOC2 SELENON SERPINH1 YY1 CREBBP TRIP4 GFPT1 IFT43 HNRNPH2 ALG2 SLC39A13 B3GAT3 RYR1 DDX3X CDC45 XYLT1 ORC1 TGFBR1 SLC2A10 RMRP SLC6A9 TGFBR2 MLXIPL TUBB3 LIMK1 ZNF469 TRMT10A ARID1B OTX2 GTF2I EFNB1 GLB1 CANT1 PIK3CA NANS CCDC47 SLC18A3 STRADA AGA KCNJ2 PIK3R1 P3H1 ACAN SLC25A1 ALG14 RAB3GAP2 VAMP1 TGDS DCHS1 WDR35 DDRGK1 LRP5 SYT1 C1R PLAGL1 PAX2 IFT122 ELN SNAP25 HERC1 ERMARD GMPPB MAP3K7 HYMAI PLOD1 LTBP4 NONO AGRN KDM6A HACD1 MED12 TBL2 EP300 SEC23A NOTCH2 SMAD3 KIF22 CHST3 COL1A1 PMM2 COL1A2
Shoulder dislocation
Genes 11
TMTC3 MAP1B ARFGEF2 ERMARD AEBP1 B3GAT3 ARF1 DYM FLNA CHST3 NEDD4L
Shoulder pain
Genes 5
PMP22 CFI CFH CD46 HELLPAR