SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report


Report for Clinical Trial NCT03342170

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

Influence of ABO Blood Group on the Risk of Complications in Alcoholic or Viral C Cirrhosis? Analysis From Two French Prospectives National Cohorts CIRRAL and CIRVIR of Patients With Alcoholic or Viral Cirrhosis Child Pugh A

The non-O blood group is a risk factor of deep vein thrombosis and recurrence of thromboembolic events, especially when associated with Factor 5 Leiden or prothrombin G20210A mutations. A recent study suggests that non-O blood group may promote portal vein thrombosis in non cirrhotic patients. In addition, in general population and chronic hepatitis C, non-O blood group combined with one or the other of the above genetic abnormalities is associated with an increased risk of liver fibrosis and accelerated fibrogenesis. The suspected mechanism could be an increased procoagulant factor VIII and an increased Willebrand plasma level, due to a low ADAMTS 13 activity, the result of which is an hypercoagulable state and a microthrombotic process. In cirrhotic patients procoagulant factors and ADAMTS 13 which are respectively increased and decreased, have be shown to be prognostic markers of hepatocellular function and portal hypertension. It has been hypothesized that the hypercoagulable state and the microthrombotic process could contribute to the worsening of the disease and enoxaparin has been shown to positively modify the prognosis of cirrhosis. The role of non-O blood group in decompensation of cirrhosis and occurrence of complications including non-tumor portal vein thrombosis has never been studied. The investigators plan a longitudinal observational study to determine the incidence of complications in alcoholic and viral cirrhosis in case of non-O blood group compared to O blood group. The aim of this study is to determine whether ABO blood group may promote complications in alcoholic or viral cirrhosis. This is an ancillary study of two national cohorts assessing natural history and hepatocellular carcinoma risk factors in alcoholic (CIRRAL) and viral (CIRVIR) cirrhosis.

NCT03342170 Alcoholic or Viral C Compensated Cirrhosis
MeSH: Fibrosis Liver Cirrhosis
HPO: Cirrhosis Hepatic fibrosis

1 Interventions

Name: G20210A prothrombin gene mutation and Factor 5 Leiden mutation

Description: blood sample

Type: Genetic

CIRRAL CIRVIR


Primary Outcomes

Description: patient follow up during 3 years

Measure: cumulated incidence of complications at 3 years

Time: from inclusion to 3 years

Time Perspective: Prospective

Cohort


There is one SNP

SNPs


1 G20210A

The non-O blood group is a risk factor of deep vein thrombosis and recurrence of thromboembolic events, especially when associated with Factor 5 Leiden or prothrombin G20210A mutations. --- G20210A ---



HPO Nodes


HPO:
Cirrhosis
Genes 119
HJV HFE MPV17 IL12A TMEM67 IL12RB1 TREX1 TCF4 KRT8 DCDC2 GLRX5 EOGT ATP6AP1 RPGRIP1L ATP7B GALT SPIB KRT18 USB1 PDGFRL RTEL1 DLL4 SFTPC CTC1 GPR35 MARS INPP5E AMACR FOS RRM2B POLG AGPAT2 AKR1D1 APC GBA PEX1 FARSB GBE1 CASP8 POU2AF1 IRF5 ATP8B1 CAV1 LBR APOE CCDC115 PPARG ACVRL1 WRAP53 SLC7A7 TYMP GDF2 NHP2 SKIV2L TERC TERT BCS1L F5 TFAM SLC40A1 IFT43 AXIN1 ABCB4 TFR2 JAK2 MST1 FAH MET PHKG2 HSD3B7 SERPINA1 LIPA AP1S1 NPHP3 IGF2R ABHD5 MMEL1 SFTPA2 PIGA ALMS1 TINF2 COG6 ARHGAP31 PIK3CA TTC37 DGUOK SLC25A13 JAG1 SCARB2 IL21R FECH RBPJ ASS1 ABCB11 DKC1 CC2D2A CYP7B1 PARN NOP10 CAVIN1 BSCL2 HAMP CTNNB1 UROD TRMT5 HBB DOCK6 ALDOB ENG TALDO1 SLC30A10 TNFSF15 TNPO3 COG4 NR1H4 NOTCH1 TP53 SMAD4 MPI
Hepatic fibrosis
Genes 103
HJV MKKS GPD1 NPHP1 IL12A RPGRIP1 TMEM67 IL12RB1 IFT27 TCF4 IFT140 DCDC2 ANKS6 EOGT RPGRIP1L OFD1 SPIB TRAF3IP1 WDR34 DLL4 DYNC2H1 GPR35 INPP5E IFT172 SDCCAG8 DZIP1L LZTFL1 CEP290 TMEM216 INSR DOLK SCYL1 GLIS3 BBIP1 FADD PEX1 BBS1 BBS2 WDR60 BBS4 POU2AF1 IRF5 BBS5 TMEM107 NHP2 NPHP4 BBS9 SLC40A1 WDPCP CEP164 MKS1 BBS10 ABCB4 CEP55 WDR19 ARL6 MST1 TTC8 MET B9D2 NEK1 LIPA AP1S1 NPHP3 MMEL1 PNPLA6 ARHGAP31 TRIM32 BBS7 AGL NEK8 ASL TTC37 DGUOK ALG9 IQCB1 RBPJ ABCD3 PKHD1 WDR35 PTRH2 B9D1 CC2D2A CYP7B1 NOP10 IFT122 IFT80 HAMP CTNNB1 C8ORF37 TMEM231 PLIN1 DOCK6 TALDO1 BBS12 CSPP1 TNFSF15 TNPO3 NOTCH1 INVS TCTN2 PMM2 MPI