To determine the improvement in diagnosis of papillary carcinoma by detecting mutation V600E BRAF in retrospective cases with inconclusive cytologic diagnosis (categories III, IV and V of Bethesda System)
Name: BRAF V600E mutation by pyrosequencing technique
Type: GeneticSelected Papillary carcinoma
Description: To determine the improvement in diagnosis of papillary carcinoma by detecting mutation V600E BRAF in retrospective cases with inconclusive cytologic diagnosis (categories III, IV and V of Bethesda System).
Measure: Improvement in diagnosis Time: 6 monthsCase-Only
There is one SNP
To determine the improvement in diagnosis of papillary carcinoma by detecting mutation V600E BRAF in retrospective cases with inconclusive cytologic diagnosis (categories III, IV and V of Bethesda System) Improvement in diagnosis. --- V600E ---
To determine the improvement in diagnosis of papillary carcinoma by detecting mutation V600E BRAF in retrospective cases with inconclusive cytologic diagnosis (categories III, IV and V of Bethesda System).. Inclusion Criteria: - Cases with histological diagnosis of papillary carcinoma (CP) and previous cytological diagnosis in groups III, IV and V Bethesda, collected between October 1989 and July 2014 in Corporació Parc Taulí Exclusion Criteria: - Non available cytological or histological material Inclusion Criteria: - Cases with histological diagnosis of papillary carcinoma (CP) and previous cytological diagnosis in groups III, IV and V Bethesda, collected between October 1989 and July 2014 in Corporació Parc Taulí Exclusion Criteria: - Non available cytological or histological material Papillary Thyroid Carcinoma Thyroid Diseases Thyroid Neoplasms Thyroid Cancer, Papillary Aim of the study To determine the improvement in diagnosis of papillary carcinoma by detecting mutation V600E BRAF in retrospective cases with inconclusive cytologic diagnosis (categories III, IV and V of Bethesda System). --- V600E ---
To determine the improvement in diagnosis of papillary carcinoma by detecting mutation V600E BRAF in retrospective cases with inconclusive cytologic diagnosis (categories III, IV and V of Bethesda System).. Inclusion Criteria: - Cases with histological diagnosis of papillary carcinoma (CP) and previous cytological diagnosis in groups III, IV and V Bethesda, collected between October 1989 and July 2014 in Corporació Parc Taulí Exclusion Criteria: - Non available cytological or histological material Inclusion Criteria: - Cases with histological diagnosis of papillary carcinoma (CP) and previous cytological diagnosis in groups III, IV and V Bethesda, collected between October 1989 and July 2014 in Corporació Parc Taulí Exclusion Criteria: - Non available cytological or histological material Papillary Thyroid Carcinoma Thyroid Diseases Thyroid Neoplasms Thyroid Cancer, Papillary Aim of the study To determine the improvement in diagnosis of papillary carcinoma by detecting mutation V600E BRAF in retrospective cases with inconclusive cytologic diagnosis (categories III, IV and V of Bethesda System). --- V600E --- --- V600E ---
Methodology: - Identification of cases - Detection of BRAF V600E mutation, initially in histological material from the surgical specimen, and if present, detection in cytological material. --- V600E ---