SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report


Report for Clinical Trial NCT00226551

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

ß2 Adrenergic Receptor Polymorphisms and Vasodilation of Internal Mammary Artery Induced by Isoproterenol

Single nucleotide polymorphisms at codon 46 and 79 of the gene encoding for the ß2 adrenergic receptor (ß2AR) modify its pharmacological properties and may alter the response to ß2AR agonists. The goal of the present study was to evaluate the role played by the Arg16Gly and Gln27Glu polymorphisms on isoproterenol induced relaxation of internal mammary arteries segments ex-vivo. Internal mammary leftover segments were collected from 96 patients undergoing coronary artery bypass graft operation. Four rings that were prepared from each specimen were allowed to reach equilibrium with physiological Krebs solution prior to precontraction with U46619. Using the organ bath technique, cumulative dose response curve of isoproterenol was constructed and mean EC50 calculated for each patient.

NCT00226551 Coronary Disease
MeSH: Coronary Disease Coronary Artery Disease
HPO: Coronary artery atherosclerosis

1 Interventions

Name: Isoproterenol

Type: Drug


Primary Outcomes

Measure: Mean Ec50% in response to rising concentration of isoproterenol

Allocation: Non-Randomized

Single Group Assignment


There are 2 SNPs

SNPs


1 Q27E

The goal of the present study was to evaluate the role played by the Arg16Gly and Gln27Glu polymorphisms on isoproterenol induced relaxation of internal mammary arteries segments ex-vivo. --- Arg16Gly --- --- Gln27Glu ---


2 R16G

The goal of the present study was to evaluate the role played by the Arg16Gly and Gln27Glu polymorphisms on isoproterenol induced relaxation of internal mammary arteries segments ex-vivo. --- Arg16Gly ---



HPO Nodes


HPO:
Coronary artery atherosclerosis
Genes 34
TGFB2 TGFB3 TGFBR1 LDLRAP1 TGFBR2 MFAP5 APOA1 APOB ABCA1 MYH11 ELN LIPC FBN1 PRKG1 APOE PPARG ZMPSTE24 MYLK LMNA CYP7A1 SERPIND1 LDLR LOX MAT2A ABCG5 ABCG8 KCNJ5 ESR1 ZNF687 SMAD3 PCSK9 CEP19 ACTA2 FOXE3