The purpose of this study is to verify the discriminatory value of previously identified salivary transcriptome and proteome markers for oral squamous cell cancer in an intended use population of patients with oral lesions suspicious for cancer.
Name: saliva collection prior to clinically driven oral biopsy
Description: cell free saliva to be used to measure mRNA and proteins by PCR and ELISAType: Otheroral lesions
Description: Based on multimarker test score
Measure: Test specificity at 90% sensitivity Time: at study completion as well as after model development following enrollment of the first 30 patents with cancerDescription: Based on comparison of cancer and controls
Measure: Validation of individual mRNA and protein markers Time: After enrollment of 30 patients with cancerDescription: Based on combined sensitivity and specificity
Measure: Validation of a pre-specified multi marker model Time: After enrollment of 30 patients with cancerCase-Control
There is one SNP
Six pre-specified mRNA markers (IL1b, IL8, SAT, DUSP1, OAZ1 and S100P) are measured by polymerase chain reaction. --- S100P ---