The purpose of this study is to verify the discriminatory value of previously identified salivary transcriptome and proteome markers for oral squamous cell cancer in an intended use population of patients with oral lesions suspicious for cancer.
Name: saliva collection prior to clinically driven oral biopsyDescription: cell free saliva to be used to measure mRNA and proteins by PCR and ELISAType: Other
Description: Based on multimarker test scoreMeasure: Test specificity at 90% sensitivity Time: at study completion as well as after model development following enrollment of the first 30 patents with cancer
Description: Based on comparison of cancer and controlsMeasure: Validation of individual mRNA and protein markers Time: After enrollment of 30 patients with cancer
Description: Based on combined sensitivity and specificityMeasure: Validation of a pre-specified multi marker model Time: After enrollment of 30 patients with cancer
There is one SNP
Six pre-specified mRNA markers (IL1b, IL8, SAT, DUSP1, OAZ1 and S100P) are measured by polymerase chain reaction. --- S100P ---