SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report


Report for Clinical Trial NCT00634673

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

FABP2 Ala54Thr Genotype Influences the Postprandial Serum Fatty Acids Profile in Type 2 Diabetic Patients

This study will be conducted in type 2 diabetic patient's to evaluate the if there is a different response of serum lipids after a standard meal (rich in saturated fatty acids) in patients who have the presence of a genetic alteration. This alteration that will be evaluated is a polymorphism, change of an amino acid in the gene of FABP2. This gene that can influence the absorption of lipids in the intestine and subjects who have the altered genotype (presence of T allele) can have an abnormal lipid profile as compared to subjects without this genotype.

NCT00634673 Dyslipidemia Type 2 Diabetes Mellitus
MeSH: Diabetes Mellitus Diabetes Mellitus, Type 2 Dyslipidemias
HPO: Abnormal circulating lipid concentration Diabetes mellitus Type II diabetes mellitus

1 Interventions

Name: sandwich

Description: standard meal:sandwich (7.23 kcal/kg-total energy; 43.35% fat, 21.95% protein, and 34.70% carbohydrate)

Type: Other

TT AA


Primary Outcomes

Measure: postprandial serum fatty acids

Time: 0, 2, 4,6, and 8 hours after meal

Secondary Outcomes

Measure: serum endothelin serum fibrinogen

Time: 0 and 8 hours after meal

Allocation: Non-Randomized

Parallel Assignment


There is one SNP

SNPs


1 A54T

FABP2 Ala54Thr Genotype Influences the Postprandial Serum Fatty Acids Profile in Type 2 Diabetic Patients. --- Ala54Thr ---

Inclusion Criteria: - Type 2 diabetes - homozygote to FABP2 polymorphism:TT or AA Exclusion Criteria: - age >75 years - glomerular filtration rate <30ml min-1 - with unstable angina or possible infarct or stroke in the last year Inclusion Criteria: - Type 2 diabetes - homozygote to FABP2 polymorphism:TT or AA Exclusion Criteria: - age >75 years - glomerular filtration rate <30ml min-1 - with unstable angina or possible infarct or stroke in the last year Dyslipidemia Type 2 Diabetes Mellitus Diabetes Mellitus Diabetes Mellitus, Type 2 Dyslipidemias Background: The presence of Ala54Thr polymorphism of intestinal fatty acid-binding protein 2 gene (FABP2) might influence the intestinal absorption of dietary fatty acids (FAs) and has been associated with diabetic nephropathy. --- Ala54Thr ---

Conclusion: The presence of the T allele of Ala54Thr polymorphism of FABP2 gene in type 2 diabetic patients increases absorption of dietary FAs, including the trans-unsaturated FAs, and this might turns these patients more susceptible to the effect of diet composition. --- Ala54Thr ---



HPO Nodes


HPO:
Abnormal circulating lipid concentration
Genes 190
NPC1 GPD1 NPHS1 TBXAS1 PLA2G7 LDLRAP1 UBR1 IL12A FLII IL12RB1 HNF1A PNPLA2 ABCA1 SLC29A3 SLC25A20 SETX SLC52A1 PLVAP DEAF1 ZMPSTE24 PNLIP ACADL SPIB ACADM NUP107 MYO5A ACADVL CLIP2 APOA5 CYP7A1 CETP CYP11A1 ACAD9 POLD1 FOS SYNE1 CYP19A1 NADK2 UBE3B PEX3 APTX IQSEC2 CYP27A1 AGPAT2 PSMB4 TMEM199 MC4R PSMB8 PSMB9 PEX1 PEX6 BAZ1B PEX7 PEX10 HMBS PEX12 PEX13 POU2AF1 XIAP PEX14 UNC13D APOA1 IRF5 ACTN4 NPC2 APOB HMGCL TMEM43 APOC2 OCRL APOC3 CAV1 LBR CAV3 LCAT APOE CCDC115 PPARG CPT1A RFC2 XRCC4 PEX11B SLC7A7 CPT2 GTF2IRD1 NSMCE2 HNF4A TFG TTPA LDLR AR LEP LEPR ACOX2 PEX26 POLR3A NSDHL GHR TRMU PHKA2 PHKG2 HSD3B7 LIMK1 PHYH NPHS2 LIPA GK LIPC LIPE FBN1 PANK2 GTF2I ACAD8 ABHD5 MMEL1 GPIHBP1 GLA SLC12A1 STXBP2 LMNA ALMS1 PIGH MSMO1 CCT5 SC5D KCNJ1 SGPL1 PRF1 ABCC8 AGL CIDEC DHCR7 SLC25A13 JAG1 DHCR24 GYS2 KCNJ11 LPL UCP2 SAR1B SLC22A5 SYNE2 EBP FECH DYRK1B PEX19 PEX16 ANGPTL3 DCAF17 MTTP PEX2 PEX5 FLCN DLD TRNE PYGL AKT2 SMPD1 CAVIN1 BSCL2 ALB ELN TRNK ABCD1 TRNL1 LTC4S CTNS HADH EMD TANGO2 TDP1 FHL1 PLIN1 STX11 G6PC RSPO1 PIK3R5 TNFSF15 SLC37A4 TNPO3 COG4 TBL2 ABCG5 RAB27A ABCG8 DGAT1 RAI1 PCSK9 CEP19 PMM2
Diabetes mellitus
Genes 326
SOX2 MKRN3 SOX3 MKKS SNORD115-1 SPATA7 CDKN2A HFE CERKL UBR1 PRPF31 LRAT PRSS1 TREX1 PRSS2 IFT140 ARL2BP GLRX5 SLC29A3 MAK AHI1 ABCA4 PDE4D ZBTB20 PDE6A PDE6G ZMPSTE24 IMPDH1 CEL STUB1 SPINK1 RTEL1 PDE6B LEMD3 INS HLA-DQB1 GJB4 IFT172 AMACR KIZ CDHR1 HLA-DRB1 CYP19A1 CFTR DHX38 MAFA GAS1 INSR ZFP57 MC4R GATA3 CTRC GATA6 PDX1 IPW PEX1 BBS1 PWRN1 PEX6 BBS2 DNAJC21 PEX10 CDH23 SRP54 DHDDS NDN PRPF6 GCK NDP KCTD1 AGBL5 GPR101 PTCH1 HNF4A ADAR TTPA TUB SNORD116-1 HESX1 STAT1 STAT3 TULP1 BLK BLM ARL6 IFIH1 TTC8 GJA1 PROM1 NEK2 GJB3 SAG FBN1 NEUROD1 SARS2 PNPLA6 BRCA1 ALMS1 BRAF BRCA2 PROKR2 CLCNKB TINF2 KLHL7 REEP6 FAM161A PIK3R1 GLI2 ABCC8 KCNJ11 RNASEH2C ARNT2 NPAP1 SCAPER FSCN2 DCAF17 AHR PRCD DKC1 FGF8 PLAGL1 AKT2 NOP10 FGFR1 PLCD1 GNAS PWAR1 SEMA4A HERC2 MERTK FOXH1 PLIN1 HYMAI NODAL USH2A CLRN1 CNGB1 CNGA1 EIF2AK3 MOG CDON CA4 IMPG2 PDE11A FOXP3 FOXC2 HJV PROK2 RNASEH2B KRAS TCF4 KLF11 EFL1 HNF1A BEST1 HNF1B PNPLA2 NR2E3 MAGEL2 POC1A OFD1 SLC25A4 USB1 NRL CLIP2 APOA5 CISD2 RNASEH2A CTC1 PTF1A WFS1 GPR35 POLD1 FOS RRM2B POLG AGPAT2 RBP3 WRN SLC19A2 HGSNAT GLIS3 SHH AIRE KIAA1549 FUZ BAZ1B RDH12 POMGNT1 PRPH2 ARHGEF18 DNM1L CP TWNK CPA1 CASR PCARE SAMHD1 TDGF1 AIP CAV1 PSTPIP1 FXN APOE IDH3B PPARG RFC2 XRCC4 WRAP53 SIX3 GTF2IRD1 NSMCE2 PRPF8 DLL1 NHP2 TERC TERT EDA RGR SLC7A14 AR LEP OPA1 LEPR PALB2 POLR3A RHO CRB1 ZIC2 MKRN3-AS1 CRX RLBP1 TTC7A PPP1R3A CNBP MST1 ERGIC1 LHX1 TGIF1 USP8 MLXIPL LIG4 LIMK1 EYS ARL3 LIPE OTX2 IGF1R GTF2I HMGA2 ATP6 TRNC SLC12A3 LMNA COX1 COX2 COX3 GUCA1B IFT88 CYTB SLC16A2 PRPF4 PRPF3 ELMO2 PDE8B VANGL1 SBDS EIF2S3 IER3IP1 ZNF408 CIDEC ND1 ARMC5 ND4 ND5 ND6 PRKACA PRKAR1A NKX2-5 APPL1 TRNE TRNF ROM1 ZFYVE26 PARN CAVIN1 BSCL2 TRNH RP9 RP1 ELN TRNK PAX4 RP2 TRNL1 RPGR ATM HAMP CTNS CTNNB1 C8ORF37 TRNQ TRNS1 TRNS2 POLG2 TRNV TOPORS TRNW KDSR HBB SUFU IL2RA RPE65 DNAJC3 SNRNP200 SNRPN PALLD TBL2 DISP1 EDA2R NEUROG3 TP53 CEP19 SMAD4 PCNT ZNF513
Type II diabetes mellitus
Genes 152
MKRN3 SNORD115-1 SPATA7 CERKL PRPF31 LRAT KLF11 IFT140 HNF1A BEST1 HNF1B ARL2BP NR2E3 GLRX5 MAK AHI1 MAGEL2 ABCA4 PDE6A PDE6G IMPDH1 OFD1 STUB1 SPINK1 NRL CLIP2 PDE6B IFT172 AMACR KIZ CDHR1 CYP19A1 DHX38 INSR RBP3 WRN MC4R HGSNAT PDX1 IPW KIAA1549 PWRN1 BBS2 BAZ1B PEX10 RDH12 POMGNT1 PRPH2 DHDDS ARHGEF18 PCARE NDN PRPF6 GCK IDH3B AGBL5 RFC2 XRCC4 GTF2IRD1 PRPF8 RGR TUB SLC7A14 AR SNORD116-1 TULP1 POLR3A RHO CRB1 MKRN3-AS1 CRX BLM RLBP1 PPP1R3A ARL6 TTC8 PROM1 LIG4 NEK2 LIMK1 EYS ARL3 SAG FBN1 GTF2I PNPLA6 SLC12A3 LMNA COX1 ALMS1 BRAF COX2 COX3 GUCA1B CLCNKB IFT88 KLHL7 PRPF4 PRPF3 REEP6 FAM161A ABCC8 ZNF408 ND1 ND4 ND5 ND6 NPAP1 SCAPER FSCN2 AHR PRCD TRNE TRNF ROM1 AKT2 TRNH RP9 PLCD1 RP1 ELN TRNK PAX4 RP2 TRNL1 RPGR ATM PWAR1 SEMA4A CTNNB1 C8ORF37 HERC2 TRNQ MERTK TRNS1 TRNS2 TOPORS TRNW USH2A RPE65 CLRN1 CNGB1 CNGA1 SNRNP200 SNRPN TBL2 MOG CEP19 CA4 IMPG2 PCNT ZNF513