SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report


Report for Clinical Trial NCT03780738

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

A Validation Study of The Relationship Between ALDH2 and Aortic Dissection

The purpose of this study is to validate the impact of ALDH2 Glu504Lys polymorphism on aortic dissection.

NCT03780738 Aortic Dissection
MeSH: Aneurysm, Dissecting
HPO: Arterial dissection


Primary Outcomes

Description: DNA was extracted from venous blood;genomic DNA underwent PCR amplification; finally, PCR products were purified and directly sequenced by Invitrogen Corp or Biosune Corp.Then ALDH2 genotype was distinguished depend on a G-to-A missense mutation on exon 12 of ALDH2 gene.

Measure: Number of patients with different ALDH2 genotype

Time: 1-30 days after samples collected

Time Perspective: Prospective

Case-Control


There is one SNP

SNPs


1 E504K

A Validation Study of The Relationship Between ALDH2 and Aortic Dissection The purpose of this study is to validate the impact of ALDH2 Glu504Lys polymorphism on aortic dissection. --- Glu504Lys ---



HPO Nodes


HPO:
Arterial dissection
Genes 9
COL3A1 TGFBR1 PLOD1 SMAD3 TGFBR2 COL5A1 COL5A2 TNXB COL1A1