SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report


Report for Clinical Trial NCT00972751

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

Investigation of Thioredoxin-1 Family Protein Expression in Rectal Cancer

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment. PURPOSE: This research study is looking at protein expression in tumor tissue samples from patients with stage II or stage III rectal cancer enrolled in clinical trial SWOG-9304.

NCT00972751 Colorectal Cancer
MeSH: Colorectal Neoplasms Rectal Neoplasms
HPO: Neoplasm of the large intestine Neoplasm of the rectum


Primary Outcomes

Measure: Expression of thioredoxin-1, thioredoxin-interacting protein, and hypoxia inducible factor-1 alpha

Time: upon testing of specimens

Measure: Correlation of expression of these proteins with tumor stage, disease-free survival, overall survival, and risk of recurrence

Time: upon provision of expression to Statistical Center

Time Perspective: Retrospective

Cohort


There is one SNP

SNPs


1 S9304A

S9304A Study of Protein Expression in Tumor Tissue Samples From Patients With Stage II or Stage III Rectal Cancer Enrolled in Clinical Trial SWOG-9304 RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. --- S9304A ---



HPO Nodes


HPO:
Neoplasm of the large intestine
Genes 71
FOXE1 PMS1 CDKN2A KRAS MST1 TGFBR2 STK11 MSH6 TCF4 BMPR1A PMS2 KLLN MLH3 DLC1 NRAS BRCA1 BRCA2 PDGFRA DOCK8 PIK3CA GPR35 POLD1 NTHL1 POLE SRC BUB1 SH3KBP1 BUB1B CHEK2 APC MLH1 PRKAR1A FLCN COL14A1 AKT1 RPS19 RPS20 HABP2 MSH2 FGFR3 MSH3 KEAP1 GREM1 MINPP1 SEMA4A CTNNB1 DCC BUB3 PTEN MDM2 CEP57 ENG AAGAB TRIP13 KIT EPCAM DICER1 RNF43 PALLD EP300 PALB2 SEC23B MUTYH SDHA TP53 SDHB SDHC SDHD AXIN2 SMAD4 FAN1
Neoplasm of the rectum
Genes 37
PMS1 MLH1 KRAS TGFBR2 STK11 MSH6 AKT1 RPS20 BMPR1A PMS2 MSH2 KLLN MSH3 MLH3 KEAP1 GREM1 SEMA4A PTEN PDGFRA ENG KIT EPCAM PIK3CA DICER1 RNF43 POLD1 NTHL1 POLE SEC23B MUTYH SDHA SDHB SDHC SDHD AXIN2 SMAD4 FAN1