To evaluate the efficacy of Amlodipine-folic Acid Tablets on reduction of blood pressure and plasma homocystein.
Name: Amlodipine
Description: amlodipine 5mg dailyType: Drugamolodipine
Name: amlodipine-FA tablet, low dose group
Description: 5mg amlodipine combined with 0.4 mg of folic acid, daily.Type: Drugamlodipine-FA tablet, low dose group
Name: amlodipine-FA tablet ,high dose group
Description: amlodipine 5mg and folic acid 0.8mg dailyType: Drugamlodipine-FA tablet ,high dose group
Allocation: Randomized
Parallel Assignment
There is one SNP
Polymorphism of MTHFR C677T leads to a reduction in enzyme activity, which may lead to an increased concentration of plasma homocysteine and lower levels of serum folate, particularly in those with low folate intake. --- C677T ---
In the present study, we sought to assess: (1) the efficacy and safety of Amlodipine-folic Acid Tablets in lowering blood pressure and homocystein in patients with mild to moderate hypertension and hyperhomocysteinemia (hcy≥10μmol/L);(2) if the blood pressure and homocysteine-lowering efficacy of Amlodipine-folic Acid Tablets can be modified by individual methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms. --- C677T ---
MTHFR C677T genotypes were determined for each study subject. --- C677T ---