SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report


Report for Clinical Trial NCT01789060

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

The Impact of Activated p-AKT Expression on Clinical Outcomes in Malignant Lymphoma : A Clinicopathological Study

PI3K(phosphatidylinositol 3-kinase)/AKT pathway is an important oncogenic signaling pathway. However, clinical information about the significance of p-AKT expression in malignant lymphoma is not fully understood yet. In this study, we investigated the overexpression of p-AKT and its prognostic implication in malignant lymphoma.

NCT01789060 Malignant Lymphoma P13K-AKT Pathway Deregulation
MeSH: Lymphoma
HPO: Lymphoma

1 Interventions

Name: p-AKT immunohistochemical staining

Description: p-AKT staining on the adequate paraffin-embedded biopsy specimen or unstained slides

Type: Other

p-AKT


Primary Outcomes

Measure: Difference of overall survival according to p-AKT status in malignant lymphoma

Time: study entry

Secondary Outcomes

Measure: Subgroup analysis of overall survival according to histologic subtypes (GCB vs non GCB)

Time: study entry

Other Outcomes

Measure: Subgroup analysis of overall survival according to International Prognostic Index risk groups

Time: study entry

Time Perspective: Retrospective

Cohort


There is one SNP

SNPs


1 P13K

Primary central nervous system lymphoma was excluded in this study Malignant Lymphoma P13K-AKT Pathway Deregulation Lymphoma Recently, among diverse oncogenic signaling pathways, a number of studies have focused on the significance of oncogenic PI3K/AKT (phophatidylinositol 3-kinase/serine-threonine kinase, also known as protein kinase B [PKB]) pathway. --- P13K ---



HPO Nodes


HPO:
Lymphoma
Genes 94
BLM MYC CDKN2A KRAS MYD88 RMRP RAG1 RAG2 MALT1 MSH6 RASGRP1 LIG4 TCF4 PMS2 ICOS NRAS WAS WIPF1 CD19 MS4A1 USB1 IGH TINF2 RB1 DCLRE1C TNFSF12 RTEL1 CTC1 CD27 CD28 PIK3R1 PRF1 NTHL1 TP63 POLE HLA-DRB1 NFKB1 NFKB2 RECQL4 RAD54B CHEK2 TNFRSF13C APC MLH1 TNFRSF13B DKC1 BIRC3 XIAP CASP10 NBN PRKCD COL14A1 FOXP1 CD81 PARN NOP10 CCND1 BCL10 BCL2 MSH2 CHD7 CTLA4 ATM BCL6 MAGT1 RUNX1 TNFRSF1B XRCC4 WRAP53 PTEN MDM2 FAS NHP2 ADA FASLG CR2 SH2D1A TERC AAGAB KIT TERT NSUN2 IL2RG LYST RNF43 ZAP70 DNASE1L3 TP53 RAD54L ITK STAT3 IL7R KIF11 PNP