SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report


Report for Clinical Trial NCT02956278

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

The Effects of BCRP Q141K on Allopurinol Pharmacokinetics and Dynamics

Subjects will undergo a placebo and allopurinol phase to better understand the effects of the reduced function BCRP Q141K variant on allopurinol pharmacokinetics and pharmacodynamics.

NCT02956278 Chronic Gout Hyperuricemia
MeSH: Hyperuricemia
HPO: Hyperuricemia

2 Interventions

Name: Allopurinol

Type: Drug

Allopurinol

Name: Placebo

Description: lactose placebo pill

Type: Other

Placebo


Primary Outcomes

Measure: Allopurinol/Oxypurinol Renal Clearance

Time: as determined by blood/urine levels taken over the course of one week

Measure: Uric Acid Levels

Time: as determined by blood/urine levels taken over the course of one week

Secondary Outcomes

Measure: Allopurinol/Oxypurinol steady state concentrations

Time: as determined by blood/urine levels taken over the course of one week

Measure: Allopurinol/Oxypurinol AUC

Time: as determined by blood levels taken over the course of one week

Purpose: Basic Science

Allocation: Non-Randomized

Parallel Assignment


There is one SNP

SNPs


1 Q141K

The Effects of BCRP Q141K on Allopurinol Pharmacokinetics and Dynamics. --- Q141K ---

The Effects of BCRP Q141K on Allopurinol Pharmacokinetics and Dynamics Subjects will undergo a placebo and allopurinol phase to better understand the effects of the reduced function BCRP Q141K variant on allopurinol pharmacokinetics and pharmacodynamics. --- Q141K ---

The Effects of BCRP Q141K on Allopurinol Pharmacokinetics and Dynamics Subjects will undergo a placebo and allopurinol phase to better understand the effects of the reduced function BCRP Q141K variant on allopurinol pharmacokinetics and pharmacodynamics. --- Q141K --- --- Q141K ---



HPO Nodes


HPO:
Hyperuricemia
Genes 24
ALMS1 MYC HNF4A ALDOB ACAT1 MUC1 SEC61A1 UMOD G6PC EIF2AK3 SLC37A4 HNF1B SH2B1 HMGCL HPRT1 REN TNFRSF11B TNFRSF11A SARS2 FBP1 PPARG PFKM CLDN16 PRPS1