In this study, pharmacologic effects of COMT inhibition during sleep deprivation in healthy subjects in dependence of their Val158Met genotype of COMT are studied. Potential effects are identified by measurement of vigilance and cognitive performance as well as EEG measurements during wake and sleep. - Trial with medicinal product
Name: Tolcapone
Description: 2 x 100mg Tolcapone compared to placebo (randomized, double-blind, cross-over)Type: DrugTolcapone
Name: Placebo
Type: DrugTolcapone
Description: Vigilance is measured subjectively (questionnaires and visual analogue scales) and objectively (e.g., psychomotor vigilance task: reaction times and number of lapses; waking EEG: spectral power) at 3-hour intervals during 40 hours prolonged wakefulness in 30 healthy male adults.
Measure: Evolution of vigilance during prolonged wakefulness after intake of tolcapone when compared to placebo Time: Participants will be studied during two weeksSingle Group Assignment
There is one SNP
Role of the Catechol-O-methyltransferase (COMT) in the Physiological Regulation of Vigilance In this study, pharmacologic effects of COMT inhibition during sleep deprivation in healthy subjects in dependence of their Val158Met genotype of COMT are studied. --- Val158Met ---