SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report


Report for Clinical Trial NCT03285750

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

Expression of GPR120 Receptor in Adipose Tissue of Type 2 Diabetic Subjects

G-protein coupled receptor 120 (GPR120) is a G-protein-coupled receptor whose endogenous ligands have been identified as long-chain fatty acids. Recently, it has been shown that GPR120 expression in human adipose tissue is higher in obese than in lean individuals. Interestingly, a GPR120 deficient mouse model presents an unfavorable phenotype when fed a high-fat diet with obesity, glucose intolerance and fatty liver, characteristics also found in type 2 diabetes (T2D). Moreover, in obese subjects, a single nucleotide polymorphism (R270H) has been identified that inhibits GPR120 signaling activity. The investigators now want to investigate if GPR120 expression in adipose tissue may be altered in patients with T2D compared to non-diabetic subjects and might contribute to diabetes-associated metabolic changes. Additionally, the investigators want to assess the frequency of the R270H mutant in T2D.

NCT03285750 Fatty Acid Metabolism and GPR120 Expression in Adipose Tissue


Primary Outcomes

Description: GPR expression is measured in adipose tissue of recently diagnosed type 2 diabetic patients and age- and BMI-matched normoglycemic controls

Measure: GPR120 expression in adipose tissue

Time: Expression measured at baseline (day 1)

Time Perspective: Cross-Sectional

Case-Control


There is one SNP

SNPs


1 R270H

Moreover, in obese subjects, a single nucleotide polymorphism (R270H) has been identified that inhibits GPR120 signaling activity. --- R270H ---

Additionally, the investigators want to assess the frequency of the R270H mutant in T2D. --- R270H ---



HPO Nodes