SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report


Report for Clinical Trial NCT03067415

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

A Multi Center, Randomized, Double-blind, Parallel Design, Exploratory Trial to Evaluate the Efficacy and Safety of D565H Twice Daily Versus D565 Once Daily in Primary Open Angle Glaucoma or Ocular Hypertension Patients.

Exploratory trial to evaluate the efficacy and safety of D565H twice daily versus D565 once daily.

NCT03067415 Glaucoma, Primary Open Angle Ocular Hypertension
MeSH: Hypertension Glaucoma Ocular Hypertension Glaucoma, Open-Angle
HPO: Glaucoma Hypertension

2 Interventions

Name: D565H(Latanoprost 25㎍/㎖)

Description: D565H twice daily

Type: Drug

D565H(Latanoprost 25㎍/㎖) D565(Latanoprost 50㎍/㎖)

Name: D565(Latanoprost 50㎍/㎖)

Description: D565 once daily

Type: Drug

D565H(Latanoprost 25㎍/㎖) D565(Latanoprost 50㎍/㎖)


Primary Outcomes

Description: Mean baseline intraocular pressure change Mean intraocular pressure change after 4 weeks

Measure: Change in mean intraocular pressure at 4 weeks compared to baseline

Time: Baseline, 4 weeks

Secondary Outcomes

Description: Mean baseline intraocular pressure change Mean intraocular pressure change after 2 weeks

Measure: Change in mean intraocular pressure at 2 weeks compared to baseline

Time: Baseline, 2 weeks

Description: IOP variation by measurement time

Measure: Changes in intraocular pressure by measurement time

Time: 2 weeks, 4 weeks

Other Outcomes

Description: Adverse events, history, medications, signs of vitality, physical examination, etc.

Measure: Safety assessed by the incidence of adverse event, History, Medication

Time: up to 4 weeks

Purpose: Treatment

Allocation: Randomized

Parallel Assignment


There is one SNP

SNPs


1 D565H

A Multi Center, Randomized, Double-blind, Parallel Design, Exploratory Trial to Evaluate the Efficacy and Safety of D565H Twice Daily Versus D565 Once Daily in Primary Open Angle Glaucoma or Ocular Hypertension Patients.. Exploratory Trial to Evaluate the Efficacy and Safety of D565H Twice Daily Versus D565 Once Daily Exploratory trial to evaluate the efficacy and safety of D565H twice daily versus D565 once daily. --- D565H ---

A Multi Center, Randomized, Double-blind, Parallel Design, Exploratory Trial to Evaluate the Efficacy and Safety of D565H Twice Daily Versus D565 Once Daily in Primary Open Angle Glaucoma or Ocular Hypertension Patients.. Exploratory Trial to Evaluate the Efficacy and Safety of D565H Twice Daily Versus D565 Once Daily Exploratory trial to evaluate the efficacy and safety of D565H twice daily versus D565 once daily. --- D565H --- --- D565H ---

A Multi Center, Randomized, Double-blind, Parallel Design, Exploratory Trial to Evaluate the Efficacy and Safety of D565H Twice Daily Versus D565 Once Daily in Primary Open Angle Glaucoma or Ocular Hypertension Patients.. Exploratory Trial to Evaluate the Efficacy and Safety of D565H Twice Daily Versus D565 Once Daily Exploratory trial to evaluate the efficacy and safety of D565H twice daily versus D565 once daily. --- D565H --- --- D565H --- --- D565H ---

Impossible subjects who participate in clinical trial by investigator's decision Glaucoma, Primary Open Angle Ocular Hypertension Hypertension Glaucoma Ocular Hypertension Glaucoma, Open-Angle A Multi center, Randomized, Double-blind, Parallel design, Exploratory trial to evaluate the efficacy and safety of D565H twice daily versus D565 once daily in primary open angle glaucoma or ocular hypertension patients. --- D565H ---



HPO Nodes


HPO:
Glaucoma
Genes 285
MAG SPATA7 CERKL CYP1B1 PRPF31 LRAT TREX1 IFT140 MASP1 ARL2BP MAK AHI1 ABCA4 PDE6A CENPJ PDE6G IMPDH1 ATR STUB1 DDX58 CHST14 CENPE PDE6B ATOH7 MYOC GJB4 IFT172 KIZ CDHR1 SMC1A HLA-DRB1 TRAIP DHX38 MAFA HDAC8 NAA10 DAG1 PEX1 BBS1 PEX6 BBS2 PEX10 PEX12 PEX13 DHDDS PEX14 PTPN22 SRY PRPF6 NDP RXYLT1 ACVR1 AGBL5 PEX11B PTCH1 RREB1 PTEN BCOR MFRP DCN ANKLE2 ADAR TRIP13 RS1 TUB BDNF B3GAT3 TULP1 HIRA RNU4ATAC TWIST1 TBC1D20 OVOL2 NOD2 XYLT1 ARL6 IFIH1 TTC8 GJA1 PROM1 FREM2 NEK2 ZNF469 GJB3 SAG FBN1 NF1 PXDN ATRIP CANT1 PIK3C2A KLHL7 WASHC5 REEP6 FKTN FAM161A YAP1 PIK3R1 CLN3 ASB10 DHCR7 RNASEH2C RECQL4 UFD1 BUB1 PITX2 BUB1B PITX3 SCAPER PEX19 PEX16 ADAMTS17 FSCN2 AHR PEX2 PRCD MYMK PEX5 PYCR1 ANTXR1 KMT2A CHRDL1 NHS AKT1 FGFR2 GNAQ SEMA4A MERTK POMK GMPPB PLOD1 USH2A CLRN1 CNGB1 CNGA1 NIPBL TBX1 FOXC1 KIF11 CA4 IMPG2 GP1BB CHST3 COL1A1 FOXE3 RAD21 COL2A1 COL3A1 COL4A1 POMT2 RNASEH2B VHL COL5A1 COL5A2 NDUFB11 FLNA BEST1 FAT4 NR2E3 ADAMTSL1 COL11A1 B3GLCT CCDC22 WDR36 COMT OFD1 B4GAT1 RASA1 SLC25A4 ADAMTS3 NRL CLIP2 CISD2 RNASEH2A FKRP WFS1 RBBP8 NTF4 RRM2B B3GALNT2 PEX3 PRSS56 RBP3 HGSNAT GLIS3 WT1 COX7B KIAA1549 BAZ1B RDH12 POMGNT1 PRPH2 ARHGEF18 CRPPA PCARE SAMHD1 ZSWIM6 OCRL POMT1 IDH3B RFC2 GTF2IRD1 IDUA PRPF8 TEK FAS PRDM5 CBS CREBBP RGR EXOSC2 SLC7A14 JMJD1C NLRP3 PEX26 RHO CRB1 YARS2 CRX SIX6 ESCO2 TGFB1 CRYAA RLBP1 ADAMTS10 CRYBA2 CRYBB3 LIMK1 EYS SH3PXD2B ARL3 OPTN GTF2I ARSB GZF1 POMGNT2 SEC24C GUCA1B IFT88 ARVCF SMC3 TMEM98 TIMP3 PRPF4 PRPF3 SETD5 LMX1B CCBE1 ZNF408 BTNL2 VCAN SBF2 EBP PTCH2 PUS1 AGK LRP5 ROM1 CEP152 RP9 LTBP2 RP1 ELN RP2 RPGR PAX6 C8ORF37 SLC4A4 BUB3 TOPORS FUT8 KDSR SUFU CEP57 RPE65 HCCS SNRNP200 PLK4 TRIM44 TBL2 CDH11 EP300 PCNT ZNF513 LARGE1
Hypertension
Genes 282
MKKS TET2 LDLRAP1 HGD IL12B TMEM67 DNAJB11 POU6F2 MYH7 PDE3A MYH11 ERCC4 PRTN3 ERCC6 DIS3L2 ZMPSTE24 MYLK TRAF3IP1 HLA-B ACAT1 TMEM237 LEMD3 HLA-DPA1 HLA-DPB1 ENPP1 CYP11B1 IFT172 MAT2A CYP11B2 CYP17A1 HLA-DRB1 CYP21A2 MAX SDCCAG8 B2M KIF1B CD2AP TRPC6 ACTA2 MC4R GBA BBS1 BBS2 CDH23 BBS4 HMBS PTPN22 HPSE2 IRF5 ACTN4 GCH1 EXT2 TNFRSF11A KCTD1 ACVRL1 GPR101 MDH2 RREB1 WNK1 NPHP4 TRIP13 ADA2 BBS9 BANF1 NFU1 ALX4 STAT1 PHF21A MKS1 HIRA NOD2 SLC52A3 LRIG2 ARL6 JAK2 SLC2A10 TTC8 ERCC8 KLHL3 GJA1 BMPR2 FBN1 GANAB NF1 CLCN2 GLA GPC3 MGP ALMS1 BRCA2 SDHAF2 FIG4 ARHGAP31 NFIX KCNJ5 SCN2B TMEM70 UFD1 PKD1 PKD2 SCNN1A PKHD1 SCNN1B WDR35 FGA SCNN1G MYMK CC2D2A MAFB CACNA1H NR3C2 CCR6 FGFR2 GNAS HSD11B2 SLC52A2 NME1 FH PLIN1 ADAMTSL4 ABCG5 ABCG8 WNK4 NOTCH1 TBX1 NOTCH2 SDHA FOXF1 NOTCH3 SDHB SDHC SDHD PCSK9 PDE11A GP1BB COL1A1 FOXE3 MPL COL3A1 NPHP1 CUL3 VHL COL4A3 COL4A4 COL4A5 CACNA1D COL5A1 COL5A2 IFT27 KRT8 FMO3 RPGRIP1L FMR1 FN1 COMT OFD1 MLX SH2B3 KRT18 CLIP2 CALR SMARCAL1 LZTFL1 CEP290 WRN WT1 BBIP1 ITGA8 ELP1 FUZ BAZ1B POR ABCB6 APOA1 POU3F4 PAM16 APOB GATA5 AIP CAV1 BBS5 REST CPOX RET NR3C1 PPARG OSGEP RFC2 GTF2IRD1 ECE1 IDUA NSMCE2 SERPINA6 LARS2 TMEM127 EDA CBS LDLR JMJD1C ABCC6 WDPCP CEP164 TNFRSF11B BBS10 WDR19 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3 MFAP5 USP8 MLXIPL ANGPTL6 LIMK1 VAC14 NPHP3 GTF2I THPO TRNC SEC24C LMNA COX1 COX2 COX3 EGFR ARVCF GUCY1A1 SUGCT CYTB LMX1B TRIM32 TRIM28 BBS7 PDE8B VANGL1 LOX ND1 ARMC5 IQCB1 XPNPEP3 ND4 ND5 DYRK1B ND6 PRKACA PRKAR1A NKX2-5 TRNE TRNF YY1AP1 CCN2 BSCL2 TRNH CTLA4 ELN TRNK TRNL1 PRKG1 C8ORF37 TRNQ TRNS1 TRNS2 TRNV TRNW HBB LYZ ENG MUC1 BBS12 G6PC SLC37A4 TBL2 EDA2R H19 COQ7 TP53 SMAD3 CEP19 SMAD4 INVS SMAD6