SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report


Report for Clinical Trial NCT00879632

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

Brain Derived Neurotrophic Factor as a Predictor of Response to Treatment in Bipolar Depression and Mania: 16-weeks Follow-up Study

There is sound evidence that quetiapine is effective in the treatment of manic and depressive episodes associated with Bipolar Disorder (BD) (Yatham et al 2006). However, even with the development of effective new treatment options, not all patients respond to treatments available. Biological markers have been investigated as predictors of response to treatment and of remission of symptoms. This would explain in part the individual's differences in the response to treatment, taking into account the genetic variability plus environmental factors influencing specific biological markers. A potential biological marker of response to treatment in BD would be the levels of neurotrophins, as they are, in fact, altered during acute mood episodes (Cunha et al 2006). Among neurotrophins, the Brain-Derived Neurotrophic Factor (BDNF) has been repeatedly and consistently reported to be associated with BD physiopathology (Post 2007). Furthermore, medications that are known to be effective in BD, like lithium and divalproex, increase BDNF levels.

NCT00879632 BIPOLAR DISORDER
MeSH: Depression Bipolar Disorder
HPO: Bipolar affective disorder Mania


Primary Outcomes

Measure: Hamilton depression raing scale and young mania rating scale

Time: 16 weeks

Secondary Outcomes

Measure: Serum BDNF levels as predictor of response to treatment

Time: 16 weeks

Time Perspective: Prospective

Cohort


There is one SNP

SNPs


1 V66M

Interestingly, a single nucleotide polymorphism at nucleotide196 (G/A) in the human BDNF gene at codon 66 (Val66Met) have been reported to be associated with a predisposition to BD in family-based studies (Rybakowski et al 2006, Green et al 2006). --- Val66Met ---

Furthermore, there are consistent findings in BD regarding the association of Val66Met polymorphism of BDNF gene with prefrontal cognitive impairment, which was recently confirmed in a large sample of bipolar subjects (Rybakowski et al 2006). --- Val66Met ---

In addition, crosssectional studies showed that the polymorphism of BDNF gene (Val66Met) was associated with response to lithium prophylaxis, but findings were not universal (Rybakowski et al 2005, Masui et al 2006). --- Val66Met ---

We also aim to investigate the polymorphism of BDNF gene (Val66Met) and its correlation with BDNF serum levels and treatment response. --- Val66Met ---



HPO Nodes


HPO:
Bipolar affective disorder
Genes 23
COMT SEC24C POLG2 SLC25A4 ARVCF ATP2A2 CDH23 FLI1 MECP2 TWNK USP8 JMJD1C FA2H CHRNA7 TBX1 RRM2B POLG RPS6KA3 UFD1 HIRA GP1BB CLCN4 RREB1
Mania
Genes 23
COMT SEC24C POLG2 SLC25A4 ARVCF ATP2A2 CDH23 FLI1 MECP2 TWNK USP8 JMJD1C FA2H CHRNA7 TBX1 RRM2B POLG RPS6KA3 UFD1 HIRA GP1BB CLCN4 RREB1