SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report


Report for Clinical Trial NCT03857243

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

Dual Transcranial Direct Current Stimulation (dTDCS)-Enhanced Therapy After Hemorrhagic Strokes and VEGF

This study will evaluate the feasibility of dual tDCS to improve arm motor function in chronic stroke patients. In addition it will collect pilot data on the blood biomarkers associated with treatment effect.

NCT03857243 Hemorrhagic Stroke Hemiparesis
MeSH: Stroke Paresis Intracranial Hemorrhages
HPO: Cerebral hemorrhage Hemiparesis Intracranial hemorrhage Stroke

1 Interventions

Name: dual transcranial direct current stimulation

Description: Mild, non-invasive battery powered direct current applied to the head over the motor areas. No shaving or invasive procedures needed.

Type: Device

dTDCS plus physical therapy Sham dTDCS plus physical therapy


Primary Outcomes

Description: any adverse events that might be related to study procedures

Measure: adverse events

Time: enrollment to 3 month followup

Description: Upper extremity motor impairment scale. Scale ranges from 0 (worst, can not perform any tasks) to 66 ( performs all tasks fully).

Measure: Upper extremity Fugl-Meyer score

Time: change between before and 3 months follow-up

Secondary Outcomes

Description: Timed performance of 15 functional upper extremity tasks, 0-120 seconds, and 2 strength measures. WMFT time measurements are calculated as the arithmetic mean of rate of performance, where we calculate "how many times would a person have completed the task, had he or she been performing it continuously for 60 seconds". Therefore the results have a minimum score of 0, where the subject could not perform any of the tasks, and no pre-defined maximum score, the higher the rate score the faster the subject was able to perform the tasks. ( see Hodics et al.,2013)

Measure: Wolf Motor Function Test

Time: change between before and at 3 months follow-up

Purpose: Treatment

Allocation: Randomized

Parallel Assignment


There is one SNP

SNPs


1 V66M

Since in animal models VEGF and BDNF have a complimentary role, VEGF polymorphism may explain some of the variability in strength of association between BDNF polymorphism Val66Met and recovery. --- Val66Met ---



HPO Nodes


HPO:
Cerebral hemorrhage
Genes 41
COL4A1 FGA CFH TGFB3 FGB VHL JAK2 USP18 FCGR2C CD46 CCM2 FGG RET COLGALT1 ACVRL1 APP FH FN1 MDH2 CPT2 GDF2 CFI SH2B3 PDCD10 SDHAF2 ENG TMEM127 ABCC6 F13A1 F13B MAX SDHA SDHB SDHC KIF1B SDHD KRIT1 SMAD4 HELLPAR PROS1 CST3
Hemiparesis
Genes 70
COL3A1 IL10 CACNA1A KRAS TPP2 IL12A TGFBR3 TREX1 ANGPTL6 EOGT TRNC COX1 COX2 RASA1 HLA-B COX3 GUCY1A1 CYTB DLL4 ERAP1 ARHGAP31 MTOR IL12A-AS1 SCN1A RHOBTB2 ND1 TLR4 RBPJ ND5 CYP26C1 ND6 GBE1 DNM1L CCR1 UBAC2 TRNF C4A PNPLA8 TUBB2B TSC1 TSC2 ALAD FGFR1 TRNK TRNL1 GNAQ TRNQ ATP1A2 ATP1A3 TRNS1 TRNS2 TRNV TRNW FAS DOCK6 ENG SP110 ADA2 SLC1A3 TTR KLRC4 OPA1 SLC2A1 MEFV IL23R NOTCH1 PRNP WDR62 STAT4 TBC1D24
Intracranial hemorrhage
Genes 97
COL3A1 COL4A1 CFH COL4A2 VHL CACNA1D USP18 MYH11 SPARC SAMD9 ATP7A RNF168 MYLK WAS FN1 WIPF1 SH2B3 DOCK8 CYP11B1 MAT2A ACAD9 CYP11B2 MAX KIF1B ACTA2 CD109 GATA2 GBA GCDH CD46 ITGA2 ITGA2B RET COLGALT1 ACVRL1 APP MDH2 CPT2 PTEN GDF2 CFI F2 TMEM127 ADA2 ITGB3 CBS F7 F10 ABCC6 F13A1 F13B KRIT1 HELLPAR IVD TGFB2 TGFB3 JAK2 TGFBR1 TGFBR2 TGFBR3 MFAP5 FCGR2C ANGPTL6 CCM2 FBN1 LMNA SDHAF2 LOX KCNJ5 CYP26C1 CST3 FGA FGB ELN GNAQ PRKG1 FGG FH SERPINF2 PDCD10 ENG PCCA PCCB MMUT SDHA NOTCH3 SDHB SDHC SMAD3 SDHD ALPL SMAD4 GP1BA PROS1 GP1BB FOXE3 PMM2
Stroke
Genes 117
MPL COL3A1 COL4A1 VHL TET2 TPP2 MYD88 COL5A1 FLNA TREX1 NPPA MYH11 HTRA1 ZMPSTE24 MYLK SH2B3 CLIP2 WFS1 CALR CYP11B1 MAT2A ACAD9 SMARCAL1 ACTA2 ACTB SLC19A2 GATA4 GATA6 ACTG1 BAZ1B DPM3 NR3C1 CPS1 ACVRL1 RFC2 APP GTF2IRD1 GDF2 ADA2 CBS MECP2 TTR ZAP70 ABCC6 NR2F2 NAGS SNAP29 STIM1 TGFB2 TGFB3 JAK2 TGFBR1 SLC2A10 TGFBR2 TGFBR3 CRELD1 MFAP5 MLXIPL ANGPTL6 LIMK1 OTC CCM2 FBN1 GTF2I THPO GLA PIGA TRNC LMNA COX1 COX2 COX3 GUCY1A1 PIK3C2A CYTB MTHFR LOX GYS1 JAG1 ND1 ND4 SCN5A ND5 AGXT ASS1 DYRK1B ND6 CST3 KCNQ1 TRNF TRNH ELN TRNK TRNL1 GNAQ PRKG1 RFT1 TRNQ PRKAG2 TRNS1 TRNS2 TRNV TRNW HBB ENG TNXB TBL2 MMUT PRNP TP53 NOTCH3 SMAD3 SMAD4 SON PCNT FOXE3 PMM2