SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report


Report for Clinical Trial NCT01936051

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

Modeling Between Plasma Concentration and Serotonin Transporter Occupancy Induced by Escitalopram in Obsessive-compulsive Disorder(OCD) Patients

To modeling the pharmacokinetic-pharmacodynamic(PK-PD) simulation with the plasma concentration and the transporter occupancy from OCD patients treated with escitalopram. To examine the effect of G2677T/A single nucleotide polymorphism(SNP) of ABCB1 gene to the PK-PD modeling in OCD patients treated with escitalopram.

NCT01936051 OCD
MeSH: Compulsive Personality Disorder Obsessive-Compulsive Disorder
HPO: Obsessive-compulsive behavior


Primary Outcomes

Measure: serotonin transporter occupancy

Time: 72hr after oral administration of escitalopram

Secondary Outcomes

Measure: genotype

Time: baseline

Description: scale for the severity of Obsessive-compulsive symptoms

Measure: Yale-Brown Obsessive Compulsive Scale(Y-BOCS) Score

Time: baseline

Description: serotonin transporter occupancy measured at 5 hour and 24 hour after oral dose of escitalopram

Measure: serotonin transporter occupancy

Time: within the first 24hrs after oral administration of escitalopram

Description: plasma concentration of escitalopram at baseline, 1, 2, 3, 5, 8, 10, 24, 48, 72 hour after oral dose of escitalopram

Measure: escitalopram plasma concentration

Time: within 72 hours after oral administration of escitalopram

Time Perspective: Other

Other


There is one SNP

SNPs


1 G2677T

To examine the effect of G2677T/A single nucleotide polymorphism(SNP) of ABCB1 gene to the PK-PD modeling in OCD patients treated with escitalopram. --- G2677T ---

To genotype G2677T/A SNP of ABCB1 gene in OCD patients treated with escitalopram. --- G2677T ---



HPO Nodes


HPO:
Obsessive-compulsive behavior
Genes 63
TLK2 TMEM106B MLXIPL LIMK1 DRD2 PANK2 GTF2I FMR1 AFF2 CLCN4 HDAC4 PSEN1 ALMS1 TRIO CLIP2 SMC3 MAPT SETD5 UBE3A PPM1D SQSTM1 TKT SLC35C1 SMC1A PCDH19 PAH HDAC8 TREM2 EHMT1 TOR1A BAZ1B KMT2A SGCE GRN XK GCH1 CHD7 ELN OCRL DPF2 MAPK1 COASY SLC45A1 RFC2 C9ORF72 DMPK GTF2IRD1 ADNP BCR NIPBL YWHAG SLITRK1 MED12 TBL2 TBX1 HNRNPH2 TTC19 CRKL KCTD17 VCP CHMP2B SEMA3E RAD21