SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report

Report for Clinical Trial NCT01074398

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

ERCC1 Expression as a Predictor of Progression Free and Overall Survival in Patients With Epithelial Ovarian Cancer Treated on GOG Protocols 0172 and 0182

RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how well patients will respond to treatment. PURPOSE: This research study is looking at biomarkers in predicting response in patients with advanced ovarian epithelial cancer, fallopian tube cancer, or primary peritoneal cancer.

NCT01074398 Fallopian Tube Cancer Ovarian Cancer Peritoneal Cavity Cancer
MeSH: Ovarian Neoplasms Carcinoma, Ovarian Epithelial Fallopian Tube Neoplasms Peritoneal Neoplasms
HPO: Fallopian tube carcinoma Ovarian neoplasm

5 Interventions

Name: gene expression analysis

Type: Genetic

Name: polymorphism analysis

Type: Genetic

Name: protein expression analysis

Type: Genetic

Name: immunohistochemistry staining method

Type: Other

Name: laboratory biomarker analysis

Type: Other

Primary Outcomes

Measure: Association between ERCC1 tumor expression and progression-free and overall survival

Secondary Outcomes

Measure: Association between ERCC1 polymorphisms and ERCC1 tumor expression

There is one SNP

SNPs

1 C8092A

Secondary - To correlate ERCC1 single-nucleotide polymorphisms (C8092A and codon 118) with ERCC1 tumor expression. --- C8092A ---


HPO Nodes

HPO:
Fallopian tube carcinoma
Ovarian neoplasm
Genes 63
RAD51 RAD51C PMS1 RAD51D CDKN2A KRAS SOX9 TGFBR2 FLI1 MRE11 MSH6 PMS2 MLH3 BRIP1 DMRT3 WWOX BRCA1 LMNA BRCA2 INHBA PIK3CA VAMP7 NR0B1 WRN CHEK2 GATA4 WT1 PTCH2 BARD1 MLH1 WNT10A NBN AKT1 C11ORF95 PRKN SRY EWSR1 RELA NR5A1 MSH2 MSH3 FGFR2 KEAP1 IDH1 IDH2 CTNNB1 PTCH1 PTEN SUFU CDH1 EPCAM DICER1 STAG3 RNF43 PALLD PALB2 OPCML TP53 MAP3K1 ZFPM2 SMAD4 FAN1 RAD50