NLP SNP

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment. PURPOSE: This research study is looking at protein expression in tumor tissue samples from patients with stage II or stage III rectal cancer enrolled in clinical trial SWOG-9304.

NCT00972751 Colorectal Cancer

MeSH: Colorectal Neoplasms Rectal Neoplasms

HPO: Neoplasm of the large intestine Neoplasm of the rectum

S9304A Study of Protein Expression in Tumor Tissue Samples From Patients With Stage II or Stage III Rectal Cancer Enrolled in Clinical Trial SWOG-9304 RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. --- S9304A ---

Primary Outcomes

Measure: Expression of thioredoxin-1, thioredoxin-interacting protein, and hypoxia inducible factor-1 alpha

Time: upon testing of specimens

Measure: Correlation of expression of these proteins with tumor stage, disease-free survival, overall survival, and risk of recurrence

Time: upon provision of expression to Statistical Center

HPO Nodes

Neoplasm of the rectum

Genes 37

PMS1 MLH1 KRAS TGFBR2 STK11 MSH6 AKT1 RPS20 BMPR1A PMS2 MSH2 KLLN MSH3 MLH3 KEAP1 GREM1 SEMA4A PTEN PDGFRA ENG KIT EPCAM PIK3CA DICER1 RNF43 POLD1 NTHL1 POLE SEC23B MUTYH SDHA SDHB SDHC SDHD AXIN2 SMAD4 FAN1

Neoplasm of the large intestine

Genes 71

FOXE1 PMS1 CDKN2A KRAS MST1 TGFBR2 STK11 MSH6 TCF4 BMPR1A PMS2 KLLN MLH3 DLC1 NRAS BRCA1 BRCA2 PDGFRA DOCK8 PIK3CA GPR35 POLD1 NTHL1 POLE SRC BUB1 SH3KBP1 BUB1B CHEK2 APC MLH1 PRKAR1A FLCN COL14A1 AKT1 RPS19 RPS20 HABP2 MSH2 FGFR3 MSH3 KEAP1 GREM1 MINPP1 SEMA4A CTNNB1 DCC BUB3 PTEN MDM2 CEP57 ENG AAGAB TRIP13 KIT EPCAM DICER1 RNF43 PALLD EP300 PALB2 SEC23B MUTYH SDHA TP53 SDHB SDHC SDHD AXIN2 SMAD4 FAN1