SNPMiner Trials: Mutation Report
Report for Mutation A227G
Developed by Shray Alag, 2019.
SNP Clinical Trial Gene
There is one clinical trial.
The investigators hypothesise that a common A277G polymorphism of the liver fatty acid
binding protein (L-FABP) gene, which leads to an amino acid exchange, may be associated with
alterations of lipid-induced hepatic insulin resistance. In the present study the
investigators will investigate potential differences in lipid-induced hepatic insulin
resistance, and in the relation between glycogenolysis and gluconeogenesis, in healthy
subjects with the A277G polymorphism vs. subjects carrying the wildtype.
NCT00277342 Wildtype Polymorphism Liver FABP Procedure: measurement of lipid-induced hepatic insulin resistance
Only one common non-synonymous polymorphism (A227G)
leading to an amino-acid exchange in the exonic region of the L-FABP gene has been previously
identified. --- A227G ---
Primary Outcomes Measure
: lipid-induced hepatic insulin resistance(WT vs.SNP L-FABP)
: changes in the relation GNG to GL
Secondary Outcomes Measure
: changes in peripheral plasma glucose and lipid responses
Genes 56BLK PPP1R3A KLF11 HNF1A HNF1B IGF1 LIPE NEUROD1 IGFALS ZMPSTE24 SLC12A3 CEL LMNA ALMS1 CLCNKB PTF1A INS PIK3R1 POLD1 FOS ABCC8 CYP19A1 CIDEC KCNJ11 AGPAT2 INSR ZFP57 WRN DCAF17 GATA6 PDX1 MFN2 APPL1 PLAGL1 AKT2 CAVIN1 BSCL2 HSD3B2 DBH GCK LMNB2 PAX4 CAV1 HSD11B1 PPARG XRCC4 NSMCE2 PLIN1 HNF4A HYMAI EIF2AK3 LEP LEPR STAT3 CEP19 PMM2