While both conventional and advanced MRI techniques offer important insights into MS pathophysiology, important aspects of this inflammatory disorder are undetectable with existing MRI technology. In Multiple Sclerosis (MS), there is growing interest in PET as an imaging modality that can increase the investigator's understanding of the disease processes and may add to an understanding of MS phenotype, particularly when combined with advanced MRI techniques such as myelin water imaging.
Description: To show an increase in 11C-PBR28 binding in all sub-types of MS compared to healthy controls.Measure: Whole Brain PBR28 binding Time: January 2020
Description: To quantitatively measure the brain levels of water located within myelinMeasure: Myelin Water Imaging by MRI Time: January 2020
Description: To correlate brain levels of inflammation measured by 11C-PBR28 with Retinal Nerve Fiber Layer (RNFL) thickness on Optical Coherence Tomography (OCT).Measure: Optical Coherence Tomography Time: January 2020
Description: To correlate brain levels of inflammation and myelin measured by PET with cognitive dysfunction in MS patients.Measure: MS Spectroscopy Time: January 2020
There is one SNP
- Mixed affinity binder according to rs6971 TSPO polymorphism1.
Exclusion Criteria: - Low and high affinity binders according to rs6971 TSPO polymorphism - Subject pregnant or breastfeeding.
A separate pre-screening consent form will be issued for the TSPO rs6971 polymorphism and eGFR blood samples, a separate pre-screening step.
Eligible participants, according to their TSPO rs6971 polymorphism will be presented a separate study consent form to continue into the clinical trial.