SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report


Report for Clinical Trial NCT01682655

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

The Influence of Apolipoprotein C3 Variants on Liver Steatosis and Serum Liver Enzyme Values in Obese Children

In the past decades, obesity in children is much more prevalent in the world. Given the increasing prevalence of pediatric obesity worldwide, fatty liver incidence is on the rise. Genetic variant in apolipoprotein C3 (APOC3) gene is associated with increased liver fat content in adults. The aim of this study is to find out whether APOC3 single nucleotide polymorphism (SNP) influence fatty liver in obese children and adolescent.

NCT01682655 Fatty Liver Obesity
MeSH: Fatty Liver
HPO: Hepatic steatosis


Primary Outcomes

Measure: genotype distribution of APOC3 rs2854117 and rs2854116 polymorphisms in subjects with and without liver steatosis

Time: Oct 2013 ~ Dec 2014

Secondary Outcomes

Measure: genotype distribution of APOC3 rs2854117 and rs2854116 polymorphisms in subjects with and without insulin resistance

Time: Oct 2013 ~ Dec 2014

Time Perspective: Prospective

Cohort


There are 2 SNPs

SNPs


1 rs2854116

genotype distribution of APOC3 rs2854117 and rs2854116 polymorphisms in subjects with and without liver steatosis.

genotype distribution of APOC3 rs2854117 and rs2854116 polymorphisms in subjects with and without insulin resistance.

Inclusion Criteria: - Age 6-18 years old - Obesity definition: BMI > 95% according to the age- and gender-specific standard suggested by National Health Institute in Taiwan - Willing to give written informed consent by parents Exclusion Criteria: - Alcohol consumption - Chronic liver diseases, including hepatitis B, hepatitis C, Wilson disease and autoimmune hepatitis - Major systemic diseases, including cardiopulmonary disease, renal failure, cancer, and psychotic disorder Inclusion Criteria: - Age 6-18 years old - Obesity definition: BMI > 95% according to the age- and gender-specific standard suggested by National Health Institute in Taiwan - Willing to give written informed consent by parents Exclusion Criteria: - Alcohol consumption - Chronic liver diseases, including hepatitis B, hepatitis C, Wilson disease and autoimmune hepatitis - Major systemic diseases, including cardiopulmonary disease, renal failure, cancer, and psychotic disorder Fatty Liver Obesity Fatty Liver The primary aim of this study is to assess the associations between to investigate the association of rs2854117 C > T and rs2854116 T > C SNPs of the APOC3 gene with liver steatosis, as measured by liver ultrasound.

As a secondary aim, the investigators will examine the associations between APOC3 rs2854117 C > T and rs2854116 T > C SNPs and serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels.


2 rs2854117

genotype distribution of APOC3 rs2854117 and rs2854116 polymorphisms in subjects with and without liver steatosis.

genotype distribution of APOC3 rs2854117 and rs2854116 polymorphisms in subjects with and without insulin resistance.

Inclusion Criteria: - Age 6-18 years old - Obesity definition: BMI > 95% according to the age- and gender-specific standard suggested by National Health Institute in Taiwan - Willing to give written informed consent by parents Exclusion Criteria: - Alcohol consumption - Chronic liver diseases, including hepatitis B, hepatitis C, Wilson disease and autoimmune hepatitis - Major systemic diseases, including cardiopulmonary disease, renal failure, cancer, and psychotic disorder Inclusion Criteria: - Age 6-18 years old - Obesity definition: BMI > 95% according to the age- and gender-specific standard suggested by National Health Institute in Taiwan - Willing to give written informed consent by parents Exclusion Criteria: - Alcohol consumption - Chronic liver diseases, including hepatitis B, hepatitis C, Wilson disease and autoimmune hepatitis - Major systemic diseases, including cardiopulmonary disease, renal failure, cancer, and psychotic disorder Fatty Liver Obesity Fatty Liver The primary aim of this study is to assess the associations between to investigate the association of rs2854117 C > T and rs2854116 T > C SNPs of the APOC3 gene with liver steatosis, as measured by liver ultrasound.

As a secondary aim, the investigators will examine the associations between APOC3 rs2854117 C > T and rs2854116 T > C SNPs and serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels.



HPO Nodes


HPO:
Hepatic steatosis
Genes 102
GABRD GPD1 HFE MPV17 LDLRAP1 TRAPPC11 HNF1B PNPLA2 ATP6AP1 ATP7B ZMPSTE24 ACADL ACADM ACADVL EARS2 LYRM4 DNAJC19 CYP7A1 MARS IARS ACAD9 POLD1 FOS ACOX1 RRM2B CYP19A1 POLG MRPL44 VPS33A AGPAT2 ETFA ETFB TMEM199 ETFDH LARS KCNAB2 FARSB COX15 APOB LMNB2 CAV1 MCCC1 APOE PPARG CPT1A XRCC4 TARS2 CPT2 SKI NSMCE2 TYMP HNF4A BCS1L HNRNPA1 CBS TFAM HNRNPA2B1 LDLR SLC40A1 COA8 DDOST PGM1 POLR3A ADK TRMU MRPS7 LRPPRC LIPA LIPE ABHD5 FBP1 NDUFAF1 LMNA ALMS1 CLPB COG6 DGUOK CIDEC SLC25A13 SAR1B SLC22A5 AKT2 CAVIN1 BSCL2 HADHA HADHB RERE HADH RMND1 HSD17B4 PLIN1 CARS2 ALDOB PRDM16 ABCG5 PCK1 ABCG8 PCK2 VCP PCSK9 CEP19 PMM2