The effects of Mediterranean Diet (MedDiet) on clinical, biochemical and inflammatory profile in NAFLD patients with simple steatosis. Potential associations of single nucleotide polymorphisms to diet composition and patients' profile were also investigated.
Name: Mediterranean Diet
Description: Participants were instructed to include vegetables, whole grains and fruits in their diet and increase fish, legumes and raw nut intake. Emphasis was given to extra virgin olive oil as the main added fat in meals. Particular attention was drained to decrease fermented dairy and poultry, with small amounts of red meat and homemade sweets. All participants were given meal plans in which the distribution of nutrients in relation to total caloric value was as follows: 40% of total energy as fat (50% as MUFAs), 20% as protein, 40% as carbohydrate, 300mg/d as dietary cholesterol and 20-30g fiber/d.Type: OtherMeditteranean Diet
Description: A decrease in liver fat
Measure: Regulation of hepatic steatosis Time: Change from Baseline to 6 monthsDescription: Increase in MedDietScore
Measure: Adherence to MedDiet Time: Change from Baseline to 6 monthsDescription: Decrease in visfatin levels
Measure: Regulation of visfatin Time: Change from Baseline to 6 monthsDescription: Decrease in oxLDL levels
Measure: Regulation of oxLDL Time: Change from Baseline to 6 monthsDescription: Decrease in visfatin in carriers of the risk allele
Measure: Association of single nucleotide polymorphisms to response to dietary treatment Time: Change from Baseline to 6 monthsSingle Group Assignment
There are 2 SNPs
Furthermore, genotyping of STAT3 rs2293152 and GCKR rs1260326 single nucleotide polymorphisms takes place.
Furthermore, genotyping of STAT3 rs2293152 and GCKR rs1260326 single nucleotide polymorphisms takes place.