SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report


Report for Clinical Trial NCT02126735

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

Metabolic and Cardiovascular Impact of CD36 Deficiency in African Americans

CD36, a protein that facilitates tissue uptake of fat, as a common link between blood fat concentrations and metabolic disease states such as diabetes mellitus. Genetic variants in the CD36 gene are more common in African Americans compared to Whites and it may confer protection against metabolic diseases by altering the amount of fat in the blood. The purpose of this study is to compare the levels of fat in the blood and to assess endothelial dysfunction among carriers versus non-carriers of the coding SNP, rs3211938 of the CD36 gene after a high fat meal challenge

NCT02126735 Obesity


Primary Outcomes

Description: We expect that subjects heterozygous for the minor allele of CD36 rs3211938 (G/T) would have an increase of 250 units in the area under the curve for triglycerides which is ~50% of the observed difference between patients with CD36 deficiency and normal controls. Assuming that the common standard deviation is 199, using a two group t-test with a type I error of 0.05, a total of 28 subjects (14 carriers and 14 non-carriers) would provide 90% power to detect a difference in our primary endpoint between carriers versus non-carriers of genotype

Measure: Area Under the Concentration-Time Curve triglycerides levels after high fat meal

Time: Baseline values prior to high fat meal and at 10, 20, 30, 60, 120, 240 & 360 minutes

Secondary Outcomes

Description: our primary outcome will be the percent change in flow mediated dilation at baseline and 4 hours after a high fat meal (peak effect). Assuming a conservative estimate of standard deviation of 3.19 our proposed study with a total of 28 subjects (14 carriers and 14 non-carriers) would have at least 80% power with type I error of 0.05 to detect a minimum difference in the mean response of 3.5 %.

Measure: percent change in flow mediated dilation at baseline and 4 hours after a high fat meal

Time: Change from baseline in flow mediated dilation at 4 hours after high fal meal

Time Perspective: Cross-Sectional

Case Control


There is one SNP

SNPs


1 rs3211938

The purpose of this study is to compare the levels of fat in the blood and to assess endothelial dysfunction among carriers versus non-carriers of the coding SNP, rs3211938 of the CD36 gene after a high fat meal challenge Area Under the Concentration-Time Curve triglycerides levels after high fat meal.

We expect that subjects heterozygous for the minor allele of CD36 rs3211938 (G/T) would have an increase of 250 units in the area under the curve for triglycerides which is ~50% of the observed difference between patients with CD36 deficiency and normal controls.



HPO Nodes