The purpose of this study is to assess the ability of common genetic variants in aggregate to predict drug-induced QT prolongation in healthy subjects using moxifloxacin.
Name: Moxifloxacin 400mg once timeType: Drug
Name: PlaceboType: Drug
Description: We will measure the QT interval on ECG up to 6 hours after administration of moxifloxacin or placeboMeasure: QT interval duration Time: 6 Hours
There is one SNP
For example, SNP rs12143842 is a C/T SNP; for each copy of the T allele the QT interval is 3.50 msec higher such that individuals with the TT genotype have a QT interval 7 msec higher than those with CC genotype and individuals with the CT genotype have a QT interval 3.5 msec higher.