SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report


Report for Clinical Trial NCT01936480

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

Genetics of QT Response to Moxifloxacin

The purpose of this study is to assess the ability of common genetic variants in aggregate to predict drug-induced QT prolongation in healthy subjects using moxifloxacin.

NCT01936480 Cardiac Arrhythmias
MeSH: Arrhythmias, Cardiac
HPO: Arrhythmia

2 Interventions

Name: Moxifloxacin 400mg once time

Type: Drug

Moxifloxacin group

Name: Placebo

Type: Drug

Placebo Group


Primary Outcomes

Description: We will measure the QT interval on ECG up to 6 hours after administration of moxifloxacin or placebo

Measure: QT interval duration

Time: 6 Hours

Purpose: Prevention

Allocation: Randomized

Crossover Assignment


There is one SNP

SNPs


1 rs12143842

For example, SNP rs12143842 is a C/T SNP; for each copy of the T allele the QT interval is 3.50 msec higher such that individuals with the TT genotype have a QT interval 7 msec higher than those with CC genotype and individuals with the CT genotype have a QT interval 3.5 msec higher.



HPO Nodes


HPO:
Arrhythmia
Genes 361
TPM1 TPM2 TPM3 HFE LDLRAP1 SOX10 TSR2 USP18 RPL26 TRPM4 RPL27 MYH6 MYH7 RPL35A EYA4 LZTR1 MYL2 PRTN3 ERCC6 MYL3 MYL4 CRLF1 ZMPSTE24 ACADL ATRX HLA-B ACADVL HLA-DPA1 ABCA12 HLA-DPB1 DNAJC19 ENPP1 HLA-DRB1 MAX KIF1B RPS7 GDAP1 RPS10 GATA1 PSMB8 GATA4 MYOZ2 RPS15A GATA6 NAA10 GBA PEX1 ACTC1 PEX6 PEX7 PEX10 CDH23 HMBS PEX12 PEX13 RPS17 PEX14 TAB2 KCNE5 PTPN22 RPS19 DAXX IKZF1 SRY TSC1 TSC2 HMGCL RPS24 TSHR RPS26 ACTN2 RPS27 RPS28 TECRL RPS29 TSPYL1 RRAS PEX11B MDH2 PTEN SGO1 HNF4A ADA2 TRDN TTN TTPA MECP2 TTR BANF1 NDUFS2 MEFV PGM1 RYR1 RYR2 FBXL4 MEN1 GPD1L SLC2A10 ERCC8 GJA1 BMP2 DES CRELD1 GJA5 JUP PHYH PTPN11 DST FBP1 GLA KCNA5 GPC3 BRAF CLCNKB SDHAF2 KCND3 CLIC2 KCNE1 PAX8 PIK3CA KCNH2 KCNJ2 ABCC8 KCNJ5 KCNJ8 SCN1B KCNJ11 SCN2B UCP2 MYPN TMEM70 SYNE2 SCN4A COQ9 A2ML1 SCN4B SCN5A GPC4 SCN9A SLMAP CIZ1 GLUL PEX19 SCN10A PEX16 HRAS KCNK3 SCNN1A SCNN1B PEX2 SCNN1G PKP2 PEX5 KCNQ1 AKT1 GNA11 GNAI2 FGFR3 GNAQ DMD MTO1 PRKAG2 FH DMPK GTPBP3 PHOX2B FHL1 BRAT1 PLN KYNU ABCG5 ABCG8 SDHA TAZ SDHB SDHC SDHD PCSK9 TBX5 FOXC2 HJV COL4A1 VHL KRAS CACNA1B RAF1 CACNA1C CACNA1D KCNE2 CACNA1S HSPG2 NDUFB11 CACNA2D1 FLNC NPPA TBX3 CACNB2 HNF1A SLC25A20 FBLN5 KCNE3 FMO3 NRAS WAS ANK2 DSC2 WIPF1 CALM1 RASA2 SLC25A4 CALM2 HCN4 DSG2 HTRA2 CLIP2 CALM3 DSP DTNA ACAD9 FOS SYNE1 RRM2B POLG PEX3 EFEMP2 AGPAT2 GPX4 SLC19A2 LAMA2 COX7B ELP1 JPH2 BAZ1B OAS1 ABCC9 TWNK CASQ2 CASR SALL4 LAMP2 XK APOB TMEM43 GATA5 SPECC1L CAV1 CAV3 CPOX RET PPARG CPT1A RFC2 CPT2 GTF2IRD1 ECE1 LARS2 TMEM127 CREBBP TCAP LDLR SLC40A1 TDP2 ABCC6 RBM20 CSRP3 NR2F2 PEX26 PPOX MTFMT RIT1 TGFB3 CNBP TGFBR1 TGFBR2 MFAP5 BVES TNNI3K LIMK1 LIPT1 LDB3 GTF2I ATP6 CSF2RA AKAP9 NUP155 CSF2RB TRNC SLC12A3 LMNA COX1 COX2 COX3 CYTB RANGRF COQ4 GYG1 BTNL2 TLL1 FLAD1 ND1 ISCU ND2 GNB5 ND4 ND4L MRPS14 PPA2 ND5 ND6 CTNNA3 GATAD1 NKX2-5 TRNE TRNF CAVIN1 BSCL2 TRNH CTLA4 ELN HADHA TRNK TRNL1 RPL35 HADHB EMD KCNJ18 TRNQ TANGO2 TRNS1 TNNC1 TRNS2 POLG2 TRNV TNNI3 TRNW KAT6B HBB TNNT2 PCCA PCCB PRDM16 NEXN CLCF1 HCCS TNXB RPL5 TBL2 SNTA1 EP300 GAA TOP3A TP53 RPL11 SMAD3 SCN3B MGME1 RPL15 GABRA3 RPL18 SOS1 SOS2