The aim of the study is to evaluate the pharmacokinetics of metformin in healthy Caucasians volunteers with and without the polymorphism A270S in OCT2,thus the study hypothesis is that renal clearance of metformin is affected in Caucasian with the known single nucleotide polymorphisms A270S in OCT2.
Name: Metformin
Description: A single dose study with one tablet of metformin 500 mg, time frame 24 hoursType: DrugHomozygote for the A270S wildetype Homo- or heterozygote for A270S minor alleles
Allocation: Non-Randomized
Parallel Assignment
There is one SNP
Inclusion Criteria: - Healthy volunteers - Written consent - rs316019 genotyped - Age 18-65 years old Exclusion Criteria: - Daily medication - Alcohol abuse - Pregnancy - Breastfeeding Inclusion Criteria: - Healthy volunteers - Written consent - rs316019 genotyped - Age 18-65 years old Exclusion Criteria: - Daily medication - Alcohol abuse - Pregnancy - Breastfeeding Metformin Organic Cation Transporter 2 Polymorphism,Single Nucleotide null