This study aimed to assess the correlation between the interleukin-10 (IL-10)-1082A/G polymorphism and idiopathic recurrent miscarriage (IRM) of Chinese Han. A total of 100 women with IRM and 100 control women with a successful pregnancy will be included in this study. Then genotyping will be performed.
Name: IL-10 polymorphismDescription: The IL-10 genotype will determined by polymerase chain reaction (PCR) amplication and restriction length fragment polymorphisms.Type: Genetic
CONTROL: women no miscarriage CASE: patients with IRM
Description: Identification of genetic polymorphisms that are associated with idiopathic recurrent miscarriageMeasure: genetic polymorphisms associated with idiopathic recurrent miscarriage Time: within one year (plus or minus 1 month) after surgery
Description: To explore the differential indexes in the routine blood test and blood coagulation test between patients with idiopathic recurrent miscarriage and healthy women, such as: WBC, NEU, LYM, RBC, HB, RDW, MCV, PLT, MPV, PDW, PCT, Fib, D-dimer.Measure: Indexes in the routine blood test and blood coagulation test Time: During pregnancy and three months after miscarriage
There is one SNP
The IL-10 polymorphism -1082A/G (rs1800896), which is located in the promoter region of the IL-10 gene, was reported to be implicated in the abnormal expression of IL-10 in IRM by some studies.