The investigators hypothesized that migraine without patients with many genetic loci associated with migraine (high genetic load) would be more sensitive and get provoked more migraine attacks by calcitonin gene-related peptide (CGRP) compared to patients with few genetic loci associated with migraine (low genetic load).
Name: CGRP
Description: Calcitonin-gene-related-peptide (CGRP)Type: DrugMigraine patients with high genetic load Migraine patients with low genetic load
Description: The difference in incidence of migraine-like attacks between patients with high genetic load and patients with low genetic load using verbal rating scale (VRS).
Measure: CGRP induced migraine attacks in patients with high and low genetic load Time: Change from baseline in headache intensity at 12 hours after the start of infusion of CGRPDescription: The difference in area under the curve (AUC) for headache intensity scores (0-12 hours)
Measure: CGRP induced migraine attacks in patients with high and low genetic load Time: Change from baseline in headache intensity at 12 hours after the start of infusion of CGRPParallel Assignment
There is one SNP
One of the genetic loci (rs13208321) is located in a gene (FHL5) that is associated with the regulation of cAMP-responsive elements.