SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report


Report for Clinical Trial NCT03262363

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

Interaction of Polymorphism rs35652124 With Curcumin Supplementation on NFE2L2 Gene Expression, Antioxidant Capacity and Renal Function in Patients With Early Diabetic Nephropathy

The increase in the prevalence of diabetes mellitus (DM) is one of the greatest public health challenges worldwide. Epidemiological studies have shown that DM is the leading cause of chronic kidney disease (CKD) in patients initiating renal replacement therapy. In our country, diabetes accounts for about 60% of all incidents of dialysis. On the other hand, CKD is currently considered a noxious disease because patients not only have the likelihood of progression to end-stage renal disease (ESRD), but because these renal alterations are associated with an increased risk of cardiovascular complications and premature death for the same cause. Most studies have focused on traditional risk factors (poor diet, physical inactivity and obesity) for the development and progression of renal damage, and less information exists on non-traditional factors such as oxidative stress and mainly, the low antioxidant response that characterizes both DM and nephropathy. In addition, there is a great variation in the susceptibility to and progression of kidney disease between different populations that is not explained by the presence of traditional factors and that could be triggered by genetic variations and its interaction with other components related to the environment and lifestyle. Fortunately, there is sufficient scientific evidence that early detection and modification of negative lifestyle factors can not only delay or halt the progression of the renal function decline to ESRD but can also significantly reduce the incidence of cardiovascular disease leading to premature death in most of these patients. Therefore, it is suggested that this risk may be determined by the interaction of lifestyle factors with the presence of susceptibility alleles, which may vary from one population to another. It is now known that hyperglycemia causes a state of oxidative stress and inflammation that can be counteracted by diet supplementation with some natural antioxidants such as curcumin. It has been shown that this molecule has multiple pharmacological properties: antioxidant, anti-inflammatory, cardioprotective, renoprotective, among others. In clinical trials a positive effect of curcumin has been seen in the treatment of diabetes and its complications. This has generated a relative optimism in the search for new curcumin treatment targets where oxidative stress is of great relevance, as is the case with CKD. However, there are still doubts about its efficacy as an adjuvant in the prevention of CKD. Additionally, the role played by interindividual variability in genes involved in the mechanism of action of curcumin is still incipient, more studies in this knowledge area are necessary.

NCT03262363 Chronic Kidney Diseases Diabetes Mellitus, Type 2 Polymorphism
MeSH: Diabetes Mellitus Kidney Diseases Renal Insufficiency, Chronic Diabetes Mellitus, Type 2 Diabetic Nephropathies
HPO: Abnormality of the kidney Chronic kidney disease Diabetes mellitus Nephropathy Type II diabetes mellitus

2 Interventions

Name: Curcumin/NFE2L2 A>G

Description: The administration will be orally and the patient will be instructed to take two capsules per day for one week, one in the morning 15 minutes before breakfast and another at night 15 minutes before dinner, accompanied by a cup of 240 mL of pure water. It will be indicated to continue with their usual medical treatment.

Type: Combination Product

Curcumin/NFE2L2 A Curcumin/NFE2L2 A> Curcumin/NFE2L2 A>G

Name: Placebo/NFE2L2 A>G

Description: The administration will be orally and the patient will be instructed to take two capsules for 24 weeks, one in the morning 15 minutes before breakfast and another in the evening 15 minutes before dinner, accompanied by a 240 mL cup of pure water. They will be advised to continue their usual medical treatment.

Type: Combination Product

Placebo/NFE2L2 A Placebo/NFE2L2 A> Placebo/NFE2L2 A>G


Primary Outcomes

Description: mRNA and active protein NRF2

Measure: Change from Baseline expression Gen NFE2L2 at 3 months

Time: Baseline at 3 months

Description: mRNA and active protein NRF2

Measure: Change from Baseline expression Gen NFE2L2 at 6 months

Time: Baseline at 6 months

Description: Superoxide dismutase, hemoxygenase 1, Glutathion peroxidase using the ELISA technique

Measure: Change from Antioxidant capacity at 3 months

Time: Baseline at 3 months

Description: Superoxide dismutase, hemoxygenase 1, Glutathion peroxidase using the ELISA technique

Measure: Change from Antioxidant capacity at 6 months

Time: Baseline at 6 months

Description: Glomerular Filtration Rate (Serum creatinine) and Albuminuria (Albumin/Creatinine Ratio)

Measure: Change from Renal Function at 3 months

Time: Baseline at 3 months

Description: Glomerular Filtration Rate (Serum creatinine) and Albuminuria (Albumin/Creatinine Ratio)

Measure: Change from Renal Function at 6 months

Time: Baseline at 6 months

Purpose: Treatment

Allocation: Randomized

Parallel Assignment


There is one SNP

SNPs


1 rs35652124

Interaction of Polymorphism rs35652124 With Curcumin Supplementation on NFE2L2 Gene Expression, Antioxidant Capacity and Renal Function in Patients With Early Diabetic Nephropathy.

Curcumin on NFE2L2 Gene Expression, Antioxidant Capacity and Renal Function According to rs35652124 in Diabetic Nephropathy The increase in the prevalence of diabetes mellitus (DM) is one of the greatest public health challenges worldwide.

Inclusion Criteria: - With T2DM according to the American Diabetes Association - With any time of T2DM evolution - With CKD stage 1-3a according to the K/DIGO guidelines Exclusion Criteria: - Incomplete evaluations - That they have not been attached to the assigned intervention with an established frequency of <80% - Decide to withdraw from the study Inclusion Criteria: - With T2DM according to the American Diabetes Association - With any time of T2DM evolution - With CKD stage 1-3a according to the K/DIGO guidelines Exclusion Criteria: - Incomplete evaluations - That they have not been attached to the assigned intervention with an established frequency of <80% - Decide to withdraw from the study Chronic Kidney Diseases Diabetes Mellitus, Type 2 Polymorphism Diabetes Mellitus Kidney Diseases Renal Insufficiency, Chronic Diabetes Mellitus, Type 2 Diabetic Nephropathies Aim: To evaluate the interaction between rs35652124 polymorphism and curcumin supplementation on the levels of NFE2L2 gene expression, antioxidant capacity and renal function in patients with early diabetic nephropathy (EDN).

Once they have signed the written consent they will be cited for the first blood sample collecting (5 mL) to be used for genomic DNA extraction and genotyping for the rs35652124 polymorphism.



HPO Nodes


HPO:
Abnormality of the kidney
Genes 1011
MKKS TACO1 RPL26 NRIP1 ERBB3 CTU2 SLC29A3 SF3B4 AMER1 BRIP1 ERCC4 ERCC6 NUP85 CWC27 MARS USP9X RBM10 SMC1A MAX ACP5 APC2 TMEM216 ACTB ETFA ETFB SLC6A19 ZFP57 ETFDH CD109 COQ8B NAA10 ACTG1 ACTG2 EVC DHDDS LAGE3 MCM5 IKZF1 ACTN4 CD46 EXT2 RPS26 EYA1 ACVRL1 MDH2 RREB1 ARID1A MDM2 F2 ADA IL17F MECP2 KLRC4 F10 IFT43 MEFV PHF21A RYR1 MAP3K1 TBC1D24 AXIN2 BAP1 MEN1 MEOX1 FANCA FANCC FANCD2 GREB1L FANCE SEMA3A ARL6 ACSL4 FAH TTC8 MET FANCB DACT1 FANCF FANCG SAA1 ARID1B FBN1 DLC1 SALL1 KITLG MBTPS2 SC5D COG6 FKTN YAP1 STRADA HOGA1 JAG1 AGT AGTR1 AGXT NR0B1 MITF GPC4 SCNN1A SCNN1B WDR35 FGA MLH1 SCNN1G SCO1 CC2D2A ANTXR1 KMT2A FGF8 AKT1 FGF10 FGFR1 FGFR3 FGFR2 IFT80 MAD2L2 TP53RK SLITRK6 FH SLC30A9 ALDOB LTBP4 MOCS1 ALOX12B FOXG1 MOCS2 SEC23B SDHA FOXF1 SDHB SDHC ZNF687 SDHD ALPL OPLAH FOXI1 CRTAP FOXC2 FOXE1 FLI1 FLII FLNA FLNB KLF11 DCDC2 FRAS1 FBLN5 CCDC22 DEAF1 FN1 OFD1 OSTM1 CISD2 SFTPC PUF60 FOS PEX3 CEP290 AGPAT2 ARX KCNAB2 BBIP1 APC ITGA8 TMEM138 SHH ELP1 AIRE FUZ NTNG1 SI UQCC2 DGKE APOA1 APOB LIPN MSH2 CHD7 FASTKD2 MSH3 POMT1 TMEM107 STIL APOE OSGEP SIX1 SIX3 FANCM APRT SKI PIGV FAS FASLG CCDC141 TMEM127 AQP2 SLC1A1 AR COA8 ABCC6 CEP164 SLC2A2 PEX26 SLC3A1 SLC4A1 EPG5 SLC5A2 FAN1 CEP63 SDR9C7 WDR19 MST1 ARHGDIA SETD2 VAC14 RAB3GAP1 ARL3 RAB18 PIGT VIPAS39 NPHP3 PIEZO2 STS ATP6 SLC12A1 SLC12A3 COX1 COX2 UBE2T G6PC3 COX3 ARVCF WDR11 FEZF1 SLC34A1 DYNC2LI1 TRIM32 TP63 ND1 ND2 ND3 XPNPEP3 EBP ND4 ND5 ND6 CLDN16 SNAI2 DCHS1 NUP133 B9D1 SMARCA4 RSPO2 SMARCB1 FLCN SMARCC2 SIX5 CDK5RAP2 TRNE SMARCE1 TRNF SMS CEP152 NR5A1 TRNH IFT122 TRNK TRNL1 RERE TRNN ATP1A1 TRNQ MAPKBP1 TRNS1 SLC4A4 TRNS2 OCLN TRNT TRNV FUT8 TRNW SUFU SNRPB FXYD2 MUC1 MCTP2 PRDM16 BBS12 G6PC SLC37A4 TRIM37 SLX4 MMUT H19 AFF4 RAI1 MGME1 INVS SON RAB23 GABRD ADCY10 TRAF3IP2 SOX9 MYD88 SOX10 UBR1 SOX11 ATP6V1B1 DNAJB11 INTU MYH9 MYH11 ANKS6 ATP7A DIS3L2 CENPJ ATP7B WWOX MYLK GALNT3 WDR4 ATRX MYO1E CHST14 MYO5B ERAP1 AVPR2 ZNF423 NADK2 SDCCAG8 DZIP1L B2M KIF1B TMEM126B IQSEC2 SRC GAS1 HDAC8 GATA3 GATA4 GBA BBS1 BBS2 SPART GBE1 CDH23 BBS4 SRP54 NBN SRY CCND1 GCK COL25A1 SSR4 SMOC1 PEX11B SRCAP GDF2 COQ2 ANKLE2 GPKOW ADA2 BCS1L BBS9 NDUFB8 SLC26A1 NDUFS2 HESX1 FREM1 STAT1 FGF17 STAT3 STAT4 STAT5B NUP205 NOD2 BLK LPIN1 IFIH1 CDKL5 STK11 BMP4 NEK1 NEUROD1 STX3 GANAB KISS1R TXNL4A NF1 PNPLA6 STXBP1 GLA GPC3 BRCA1 BRAF BRCA2 MAGED2 SULT2B1 NFIA KLHL7 SGPL1 GLI1 GLI2 GLI3 ABCC8 SURF1 GLIS2 BUB1 BUB1B VAMP7 C1QBP MYMK HYLS1 C1QA C1QB C1QC C3 LIPT2 GNA11 C4A TACR3 BMPER GNAS STRA6 GNB1 FOXH1 TAF13 MAP3K7 NODAL KCNQ1OT1 TALDO1 KYNU NUP160 ABCG5 ABCG8 TBX1 ALG1 NOTCH2 NOTCH3 CA2 GP1BA GP1BB SPINK5 GP9 TBX15 NPHP1 NPHS1 NPM1 CACNA1D CACNA1S IFT27 TCF4 TBX3 NCAPD3 NIPAL4 HNF1A HNF1B SLC25A20 ADAMTSL1 CAD RPGRIP1L NRAS B4GAT1 TCN2 GPR35 ROR2 NUMA1 SOX17 NSD1 BAZ1B CASP10 CASR IL17RC ADAMTS13 RIPK4 TDGF1 LMNB2 OCRL SPECC1L AIP CAV1 BBS5 SLC7A7 SERPINH1 NXN OGG1 CIT TFAP2A DICER1 CLDN10 GSN TFE3 ZFPM2 POLR3A CCND2 SLC7A9 GRIP1 TBX18 B9D2 TGIF1 TGM1 MSH6 USP8 MFSD2A KLLN GTF2I DCLRE1C SMC3 INF2 IL12A-AS1 BTNL2 SCARB2 PPP1R15B PAFAH1B1 TLR4 SLC49A4 PRDX1 PAH FIBP HAAO WDR73 CD151 HABP2 PAX1 PAX2 PAX4 PAX6 SEC63 PBX1 BUB3 KAT6B HBB PC RNF139 CDC42 TNXB DISP1 PCK1 PCK2 TP53 COX14 CDK4 CDK6 LARGE1 PIGY CDKN1B CFH CDKN1C PIGN H19-ICR HGD TMEM67 TREX1 ASXL1 POU6F2 HIC1 PDE6D GCM2 CEL HLA-B MICOS13 MNX1 CENPF PDGFRB LEMD3 HLA-DPA1 HLA-DPB1 ENPP1 HLA-DRB1 SLC26A4 CD2AP CFTR TRPC6 GDF6 COPB2 PEX1 CLEC7A PEX6 PEX7 DNAJC21 PEX10 HMBS SOX18 PEX12 PEX13 PEX14 KCNE5 HPSE2 TSC1 TSC2 CHD4 WNT4 HMOX1 CHN1 HNF4A TRIP13 PGAM2 TRIP11 CHRM3 TTR PGK1 ALX4 PGM3 HNRNPU HIRA RNU4ATAC SNAP29 PHEX ERCC8 HOXA13 COLEC11 PHYH SERPINA1 AP2S1 SLC9A3R1 DMRT3 PIGA CLCN5 CLCNKA GRHPR CLCNKB COG1 HOXD13 PIK3CA ANLN PIK3R2 SHPK DSTYK HS6ST1 HPRT1 RAB3GAP2 RECQL4 HPS1 UFD1 PKD1 PKD2 PEX16 HRAS ASPM PKHD1 UMOD LMOD1 ALG8 UMPS PLAGL1 COL14A1 CCR1 CCR6 PLCD1 IL17RA FLRT3 PLD1 PLEC PLG HSD17B4 PYCR2 SERPINF2 TMCO1 SEC61A1 EIF2AK3 KDM6A NIPBL HSPA9 PML COL1A1 PMM2 VDR COL3A1 COL4A1 POMT2 PROK2 VHL COL4A3 COL4A4 COL4A5 COL5A1 COL5A2 HSPG2 COL7A1 PIGL WAS SLC2A9 COMT WIPF1 TAPT1 ADAMTS3 CLIP2 DLL4 FKRP WFS1 NSD2 NELFA INPP5E IARS WNT3 POLE WNT5A RRM2B SMARCAL1 EFEMP2 LZTFL1 NDUFAF3 COX6B1 WRN WT1 COX8A POR COX10 PORCN XDH POU3F4 MINPP1 SLC34A3 NABP1 PPARG XRCC2 CPT1A XRCC4 CPT2 GABBR2 GTF2IRD1 CFI GDF3 KANK2 CREBBP YWHAE PREPL SHANK3 ZAP70 SH2B1 SLC22A12 MMACHC PPM1B ZIC2 ZIC3 THOC6 IGF2 PPP3CA NSMF KANSL1 SEC24C ZNF592 PRCC NEK8 TTC37 SETBP1 IQCB1 ATP6V0A4 SLC6A20 CEP135 LPIN2 CEP41 GEMIN4 PRKAR1A CYP4F22 APPL1 PRKCD CCN2 CTH CAVIN1 CTLA4 PRKCSH NUP93 CTNS CTNNB1 MAP2K1 IL17RD MAP2K2 FAM20A CEP57 IL2RG IL7R CRB2 PRODH SEMA3E CYB561 PRPS1 IL10 COX20 LDLRAP1 IL12A TCTN3 IFT140 MASP1 DDX59 AHI1 ZBTB16 PRTN3 PLVAP ZNF148 HDAC4 TRAF3IP1 TMEM237 ABCA12 PET100 INS IFT172 CYP24A1 INSL3 CYP27A1 KIAA0586 VPS33A PDX1 ITGA6 PTPN22 IRF5 CFHR5 KCTD1 KEAP1 ITGA2 ITGA2B ITGA3 DCC PTCH1 PTEN BCOR ACE NPHP4 NSUN2 ITGB3 ITGB4 ZEB2 PTH1R MRPS22 PHGDH SLC36A2 MKS1 HELLPAR KIAA0753 FBXL4 TBC1D20 NSDHL BSND LRIG2 TMEM260 MAGI2 FREM2 FAM20C ANOS1 NPHS2 PTPN11 ARL6IP6 SARS2 CEP120 ALMS1 PROKR2 CLPB VPS33B SDHAF2 FIG4 PTPRO WASHC5 FGF20 KCNH1 KCNJ1 KCNJ5 DHCR7 DHCR24 KCNJ10 KCNJ11 TMEM70 ARNT2 DHODH PEX19 PEX2 PEX5 DKC1 KIF14 KCNQ1 ALDH18A1 FIP1L1 PYGM MAFB RBM8A CDC73 AMMECR1 RMND1 DMP1 TMEM231 CPLANE1 DNA2 HYMAI DNASE1L3 IL23R JAM3 WDR62 PCSK9 CDON MOCOS KNL1 RAD21 FOXP3 RAD51 TBX22 RAD51C KRAS RAF1 RAG1 RPGRIP1 DPH1 RAG2 SCO2 AKT3 FAT4 RAP1A PDSS2 RAP1B EVC2 B3GLCT RARA RARB KRT17 MCPH1 WDR34 NUP107 DYNC2H1 COG7 RBBP8 DUSP6 TPRKB KAT6A COQ6 DVL1 DVL3 GLIS3 AGGF1 WDR60 LAMB2 SALL4 FANCL REN DPF2 REST LCAT RET RFC2 DLL1 CCNQ LDHA PQBP1 AAGAB TBL1XR1 LDLR JMJD1C WDPCP PALB2 LETM1 NARS2 NLRP3 EDNRB PHC1 RFWD3 KIF7 BBS10 CEP55 ESCO2 SLC17A5 LHX1 RMRP RASGRP1 MLXIPL LIG4 LIMK1 KMT2D TRNT1 HMGA2 LMNA ADGRG2 SETD5 LMX1B TRIM28 BBS7 VANGL1 CCBE1 SBDS FANCI ARID2 ALG9 ARMC5 SPRY4 CEP83 TTC21B MED25 LRP2 EHMT1 LRP4 SASS6 LRP5 ROBO2 UBAC2 CAMKMT ALOXE3 YY1AP1 BSCL2 ELN CLDN19 C8ORF37 EMP2 LYZ ENG CSPP1 TBL2 CD96 EP300 COQ7 RPL11 SMAD4 TCTN2 PLCE1
Chronic kidney disease
Genes 87
WDR19 RAD51C CFH NPHP1 COL4A3 COL4A4 COL4A5 MAGI2 TMEM67 ARHGDIA IFT140 DNAJB11 SAA1 HNF1B DCDC2 NPHS2 AHI1 NPHP3 SARS2 FN1 NUP85 CLCN5 TRAF3IP1 NUP107 MYO1E INF2 ANLN SGPL1 IFT172 DSTYK NEK8 JAG1 SDCCAG8 DZIP1L GLIS2 TMEM126B IQCB1 LZTFL1 CEP290 XPNPEP3 TRPC6 TPRKB AGXT CEP83 CLDN16 PKD2 COQ8B TTC21B GATA3 NUP133 WT1 LAMB2 SOX18 UMOD LAGE3 DGKE ACTN4 CD151 PAX2 REN IFT122 CLDN19 CFHR5 NUP93 OCRL CTNS TP53RK OSGEP MAPKBP1 TMEM231 SLC7A7 APRT ALDOB NPHP4 MUC1 SEC61A1 KYNU NUP160 IFT43 CEP164 SH2B1 MMUT INVS PLCE1 FAN1 NUP205 NOD2
Diabetes mellitus
Genes 326
SOX2 MKRN3 SOX3 MKKS SNORD115-1 SPATA7 CDKN2A HFE CERKL UBR1 PRPF31 LRAT PRSS1 TREX1 PRSS2 IFT140 ARL2BP GLRX5 SLC29A3 MAK AHI1 ABCA4 PDE4D ZBTB20 PDE6A PDE6G ZMPSTE24 IMPDH1 CEL STUB1 SPINK1 RTEL1 PDE6B LEMD3 INS HLA-DQB1 GJB4 IFT172 AMACR KIZ CDHR1 HLA-DRB1 CYP19A1 CFTR DHX38 MAFA GAS1 INSR ZFP57 MC4R GATA3 CTRC GATA6 PDX1 IPW PEX1 BBS1 PWRN1 PEX6 BBS2 DNAJC21 PEX10 CDH23 SRP54 DHDDS NDN PRPF6 GCK NDP KCTD1 AGBL5 GPR101 PTCH1 HNF4A ADAR TTPA TUB SNORD116-1 HESX1 STAT1 STAT3 TULP1 BLK BLM ARL6 IFIH1 TTC8 GJA1 PROM1 NEK2 GJB3 SAG FBN1 NEUROD1 SARS2 PNPLA6 BRCA1 ALMS1 BRAF BRCA2 PROKR2 CLCNKB TINF2 KLHL7 REEP6 FAM161A PIK3R1 GLI2 ABCC8 KCNJ11 RNASEH2C ARNT2 NPAP1 SCAPER FSCN2 DCAF17 AHR PRCD DKC1 FGF8 PLAGL1 AKT2 NOP10 FGFR1 PLCD1 GNAS PWAR1 SEMA4A HERC2 MERTK FOXH1 PLIN1 HYMAI NODAL USH2A CLRN1 CNGB1 CNGA1 EIF2AK3 MOG CDON CA4 IMPG2 PDE11A FOXP3 FOXC2 HJV PROK2 RNASEH2B KRAS TCF4 KLF11 EFL1 HNF1A BEST1 HNF1B PNPLA2 NR2E3 MAGEL2 POC1A OFD1 SLC25A4 USB1 NRL CLIP2 APOA5 CISD2 RNASEH2A CTC1 PTF1A WFS1 GPR35 POLD1 FOS RRM2B POLG AGPAT2 RBP3 WRN SLC19A2 HGSNAT GLIS3 SHH AIRE KIAA1549 FUZ BAZ1B RDH12 POMGNT1 PRPH2 ARHGEF18 DNM1L CP TWNK CPA1 CASR PCARE SAMHD1 TDGF1 AIP CAV1 PSTPIP1 FXN APOE IDH3B PPARG RFC2 XRCC4 WRAP53 SIX3 GTF2IRD1 NSMCE2 PRPF8 DLL1 NHP2 TERC TERT EDA RGR SLC7A14 AR LEP OPA1 LEPR PALB2 POLR3A RHO CRB1 ZIC2 MKRN3-AS1 CRX RLBP1 TTC7A PPP1R3A CNBP MST1 ERGIC1 LHX1 TGIF1 USP8 MLXIPL LIG4 LIMK1 EYS ARL3 LIPE OTX2 IGF1R GTF2I HMGA2 ATP6 TRNC SLC12A3 LMNA COX1 COX2 COX3 GUCA1B IFT88 CYTB SLC16A2 PRPF4 PRPF3 ELMO2 PDE8B VANGL1 SBDS EIF2S3 IER3IP1 ZNF408 CIDEC ND1 ARMC5 ND4 ND5 ND6 PRKACA PRKAR1A NKX2-5 APPL1 TRNE TRNF ROM1 ZFYVE26 PARN CAVIN1 BSCL2 TRNH RP9 RP1 ELN TRNK PAX4 RP2 TRNL1 RPGR ATM HAMP CTNS CTNNB1 C8ORF37 TRNQ TRNS1 TRNS2 POLG2 TRNV TOPORS TRNW KDSR HBB SUFU IL2RA RPE65 DNAJC3 SNRNP200 SNRPN PALLD TBL2 DISP1 EDA2R NEUROG3 TP53 CEP19 SMAD4 PCNT ZNF513
Nephropathy
Genes 94
WDR19 BLK COL4A1 NPHP1 TMEM67 TREX1 KLF11 COL7A1 IFT140 HNF1A SAA1 HIC1 MYH9 VIPAS39 NEUROD1 RPGRIP1L CEP120 GLA WAS CEL WIPF1 WDR4 WDR34 NUP107 VPS33B TMEM237 CISD2 DYNC2LI1 LMX1B DYNC2H1 WFS1 INS INPP5E IFT172 FOS ABCC8 ZNF423 SLC26A4 SCARB2 KCNJ10 B2M KCNJ11 PAFAH1B1 CEP290 TPRKB TMEM216 AGPAT2 PRDX1 TTC21B SCNN1A SCNN1B NUP133 WT1 FGA PDX1 TMEM138 SCNN1G WDR60 CC2D2A UMOD APPL1 LAGE3 APOA1 MAFB WDR73 CD151 CCND1 CAVIN1 BSCL2 GCK PAX4 CLDN19 IFT80 PAX6 CAV1 TP53RK PPARG OSGEP TMEM231 HNF4A LYZ FAM20A SEC61A1 ADA2 EIF2AK3 YWHAE TTR MEFV ALG1 NLRP3 MMACHC PRODH FOXI1 NOD2
Type II diabetes mellitus
Genes 152
MKRN3 SNORD115-1 SPATA7 CERKL PRPF31 LRAT KLF11 IFT140 HNF1A BEST1 HNF1B ARL2BP NR2E3 GLRX5 MAK AHI1 MAGEL2 ABCA4 PDE6A PDE6G IMPDH1 OFD1 STUB1 SPINK1 NRL CLIP2 PDE6B IFT172 AMACR KIZ CDHR1 CYP19A1 DHX38 INSR RBP3 WRN MC4R HGSNAT PDX1 IPW KIAA1549 PWRN1 BBS2 BAZ1B PEX10 RDH12 POMGNT1 PRPH2 DHDDS ARHGEF18 PCARE NDN PRPF6 GCK IDH3B AGBL5 RFC2 XRCC4 GTF2IRD1 PRPF8 RGR TUB SLC7A14 AR SNORD116-1 TULP1 POLR3A RHO CRB1 MKRN3-AS1 CRX BLM RLBP1 PPP1R3A ARL6 TTC8 PROM1 LIG4 NEK2 LIMK1 EYS ARL3 SAG FBN1 GTF2I PNPLA6 SLC12A3 LMNA COX1 ALMS1 BRAF COX2 COX3 GUCA1B CLCNKB IFT88 KLHL7 PRPF4 PRPF3 REEP6 FAM161A ABCC8 ZNF408 ND1 ND4 ND5 ND6 NPAP1 SCAPER FSCN2 AHR PRCD TRNE TRNF ROM1 AKT2 TRNH RP9 PLCD1 RP1 ELN TRNK PAX4 RP2 TRNL1 RPGR ATM PWAR1 SEMA4A CTNNB1 C8ORF37 HERC2 TRNQ MERTK TRNS1 TRNS2 TOPORS TRNW USH2A RPE65 CLRN1 CNGB1 CNGA1 SNRNP200 SNRPN TBL2 MOG CEP19 CA4 IMPG2 PCNT ZNF513