SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report


Report for Clinical Trial NCT02216370

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

Detection of Occult Paroxysmal Atrial Fibrillation in Cryptogenic Stroke Patients or TIA Using an Implantable Loop Recorder and Correlation With Genetic Markers.

Atrial fibrillation (AF) is the significant risk factor of ischemic stroke with incidence about 20% of all ischemic strokes. The undiagnosed AF in cryptogenic stroke patients could be present but not revealed by rutinne ECG.

NCT02216370 Cryptogenic Stroke or TIA Atrial Fibrillation
MeSH: Stroke Atrial Fibrillation
HPO: Atrial fibrillation Paroxysmal atrial fibrillation Stroke


Primary Outcomes

Description: Documented Atrial Fibrillation after episode of cryptogenic stroke / TIA Documented genetic mutation PITX2 chromosome 4q25, polymorphism rs1906591,rs10033464 and ZFHX3 chromosome 16q22, polymorphism rs2106261

Measure: Documented Atrial Fibrillation after episode of cryptogenic stroke / TIA Documented genetic mutation PITX2 and ZFHX3

Time: 12 months

Secondary Outcomes

Measure: Time to documented Atrial Fibrillation Reccurent stroke or TIA Stroke Secondary Prevention Therapy changes within 12 months Neuroimaging Changes ( brain CT/ MRI)

Time: 12 months

Other Outcomes

Measure: Follow-up of patients with implanted ECG monitor REVEAL XT incidence of atrial fibrillation, stroke or TIA

Time: 3 Years

Time Perspective: Prospective

Case Control


There are 3 SNPs

SNPs


1 rs10033464

Documented Atrial Fibrillation after episode of cryptogenic stroke / TIA Documented genetic mutation PITX2 chromosome 4q25, polymorphism rs1906591,rs10033464 and ZFHX3 chromosome 16q22, polymorphism rs2106261.


2 rs1906591

Documented Atrial Fibrillation after episode of cryptogenic stroke / TIA Documented genetic mutation PITX2 chromosome 4q25, polymorphism rs1906591,rs10033464 and ZFHX3 chromosome 16q22, polymorphism rs2106261.


3 rs2106261

Documented Atrial Fibrillation after episode of cryptogenic stroke / TIA Documented genetic mutation PITX2 chromosome 4q25, polymorphism rs1906591,rs10033464 and ZFHX3 chromosome 16q22, polymorphism rs2106261.



HPO Nodes


HPO:
Atrial fibrillation
Genes 62
CACNA1C KCNE2 MFAP5 CACNA2D1 TNNI3K FLNC GJA5 NPPA CACNB2 MYH7 MYL4 KCNA5 ANK2 NUP155 LMNA SLC25A4 HCN4 DTNA KCNH2 KCNJ2 FOS KCNJ5 RRM2B POLG SCN1B TLL1 SCN2B MYPN SCN4B AGPAT2 SCN5A MYOZ2 GATAD1 KCNQ1 NKX2-5 ABCC9 TWNK CASQ2 TAB2 XK CAVIN1 BSCL2 TMEM43 GATA5 ACTN2 CAV1 PPARG PRKAG2 TNNC1 DMPK POLG2 TNNI3 SGO1 TNNT2 PLN NEXN TRDN TTN CSRP3 RYR2 SMAD3 TBX5
Paroxysmal atrial fibrillation
Genes 12
CSRP3 KCNJ5 SCN1B SCN2B KCNE2 MYL4 SCN5A ABCC9 KCNA5 PRKAG2 TBX5 KCNJ2
Stroke
Genes 117
MPL COL3A1 COL4A1 VHL TET2 TPP2 MYD88 COL5A1 FLNA TREX1 NPPA MYH11 HTRA1 ZMPSTE24 MYLK SH2B3 CLIP2 WFS1 CALR CYP11B1 MAT2A ACAD9 SMARCAL1 ACTA2 ACTB SLC19A2 GATA4 GATA6 ACTG1 BAZ1B DPM3 NR3C1 CPS1 ACVRL1 RFC2 APP GTF2IRD1 GDF2 ADA2 CBS MECP2 TTR ZAP70 ABCC6 NR2F2 NAGS SNAP29 STIM1 TGFB2 TGFB3 JAK2 TGFBR1 SLC2A10 TGFBR2 TGFBR3 CRELD1 MFAP5 MLXIPL ANGPTL6 LIMK1 OTC CCM2 FBN1 GTF2I THPO GLA PIGA TRNC LMNA COX1 COX2 COX3 GUCY1A1 PIK3C2A CYTB MTHFR LOX GYS1 JAG1 ND1 ND4 SCN5A ND5 AGXT ASS1 DYRK1B ND6 CST3 KCNQ1 TRNF TRNH ELN TRNK TRNL1 GNAQ PRKG1 RFT1 TRNQ PRKAG2 TRNS1 TRNS2 TRNV TRNW HBB ENG TNXB TBL2 MMUT PRNP TP53 NOTCH3 SMAD3 SMAD4 SON PCNT FOXE3 PMM2