SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report


Report for Clinical Trial NCT03211507

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

Idiopathic Pulmonary Fibrosis Job Exposures Study

A case-control study to investigate whether job exposures are an under-recognized cause of idiopathic pulmonary fibrosis (IPF) using an interview to collect information about previous jobs and a blood test to investigate genetic susceptibility.

NCT03211507 IPF Idiopathic Pulmonary Fibrosis
MeSH: Fibrosis Pulmonary Fibrosis Idiopathic Pulmonary Fibrosis Idiopathic Interstitial Pneumonias
HPO: Pulmonary fibrosis

2 Interventions

Name: Computer-assisted telephone interview

Description: Occupational history

Type: Other

Case Controls

Name: Genetic analysis

Description: To include analysis of known susceptibility markers

Type: Genetic

Case Controls


Primary Outcomes

Description: estimated using logistic regression for any vs no asbestos exposure and adjusting for age and smoking status

Measure: Association between asbestos exposure and IPF

Time: 2 years

Secondary Outcomes

Description: estimated using logistic regression for categories of cumulative exposure and adjusting for age and smoking status

Measure: Dose-response relationship between asbestos exposure and IPF

Time: 2 years

Description: MUC5B rs35705950 and asbestos exposure odds ratio.

Measure: Gene-environment interaction (for MUC5B rs35705950 and asbestos exposure) odds ratio.

Time: 2 years

Time Perspective: Prospective

Case-Control


There is one SNP

SNPs


1 rs35705950

Gene-environment interaction (for MUC5B rs35705950 and asbestos exposure) odds ratio.. MUC5B rs35705950 and asbestos exposure odds ratio..



HPO Nodes


HPO:
Pulmonary fibrosis
Genes 57
TGFB1 RASGRP1 CLCA4 STX1A ABCA3 PRTN3 RNF168 SFTPA2 DPP9 FAM13A ALMS1 NUP107 TINF2 RTEL1 DSP SFTPC HLA-DPA1 ASAH1 HLA-DPB1 RCBTB1 HLA-DRB1 BTNL2 HPS4 CFTR HPS1 FSHR KIAA0319L PSMC3IP DKC1 CASP10 PRKCD SFTPA1 PTPN22 IRF5 PARN NOP10 CCN2 ATP11A MUC5B CCR6 NR5A1 CTLA4 CAV1 SPIDR PLEC DCTN4 AP3B1 FAS NHP2 FASLG TERC SP110 TERT MRPS22 STN1 BMP15 FAM111B