SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report


Report for Clinical Trial NCT01016444

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

β2AR Polymorphisms and Albuterol Responsiveness in Acute Asthma

The hypothesis to be tested is that acutely ill asthmatics who do not resolve their attacks following standard doses of albuterol and require admission to hospital have single nucleotide polymorphisms of their B2 adrenergic receptors that lower B2 agonist responsivity.

NCT01016444 Acute Asthma
MeSH: Asthma
HPO: Asthma


Primary Outcomes

Measure: B2AR polymorphisms associated with albuterol responsiveness in acute asthma.

Time: ~ 1 hour following 3 doses of albuterol Q 20 min

Secondary Outcomes

Measure: B2AR haplotypes

Time: ~ 1hr post 3 doses of albuterol

Time Perspective: Prospective

Case Control


There are 11 SNPs

SNPs


1 rs1042711

Eleven polymorphisms will be selected for genotyping from within the ADRB2 coding region and up to about 5 kb 5' Codon 1 (rs11958940, rs17778257, rs2895795, rs2053044, rs12654778, rs11959427, rs1042711, rs1042713, rs1042714, rs1800888, and rs1042718).


2 rs1042713

Eleven polymorphisms will be selected for genotyping from within the ADRB2 coding region and up to about 5 kb 5' Codon 1 (rs11958940, rs17778257, rs2895795, rs2053044, rs12654778, rs11959427, rs1042711, rs1042713, rs1042714, rs1800888, and rs1042718).


3 rs1042714

Eleven polymorphisms will be selected for genotyping from within the ADRB2 coding region and up to about 5 kb 5' Codon 1 (rs11958940, rs17778257, rs2895795, rs2053044, rs12654778, rs11959427, rs1042711, rs1042713, rs1042714, rs1800888, and rs1042718).


4 rs1042718

Eleven polymorphisms will be selected for genotyping from within the ADRB2 coding region and up to about 5 kb 5' Codon 1 (rs11958940, rs17778257, rs2895795, rs2053044, rs12654778, rs11959427, rs1042711, rs1042713, rs1042714, rs1800888, and rs1042718).


5 rs11958940

Eleven polymorphisms will be selected for genotyping from within the ADRB2 coding region and up to about 5 kb 5' Codon 1 (rs11958940, rs17778257, rs2895795, rs2053044, rs12654778, rs11959427, rs1042711, rs1042713, rs1042714, rs1800888, and rs1042718).


6 rs11959427

Eleven polymorphisms will be selected for genotyping from within the ADRB2 coding region and up to about 5 kb 5' Codon 1 (rs11958940, rs17778257, rs2895795, rs2053044, rs12654778, rs11959427, rs1042711, rs1042713, rs1042714, rs1800888, and rs1042718).


7 rs12654778

Eleven polymorphisms will be selected for genotyping from within the ADRB2 coding region and up to about 5 kb 5' Codon 1 (rs11958940, rs17778257, rs2895795, rs2053044, rs12654778, rs11959427, rs1042711, rs1042713, rs1042714, rs1800888, and rs1042718).


8 rs17778257

Eleven polymorphisms will be selected for genotyping from within the ADRB2 coding region and up to about 5 kb 5' Codon 1 (rs11958940, rs17778257, rs2895795, rs2053044, rs12654778, rs11959427, rs1042711, rs1042713, rs1042714, rs1800888, and rs1042718).


9 rs1800888

Eleven polymorphisms will be selected for genotyping from within the ADRB2 coding region and up to about 5 kb 5' Codon 1 (rs11958940, rs17778257, rs2895795, rs2053044, rs12654778, rs11959427, rs1042711, rs1042713, rs1042714, rs1800888, and rs1042718).


10 rs2053044

Eleven polymorphisms will be selected for genotyping from within the ADRB2 coding region and up to about 5 kb 5' Codon 1 (rs11958940, rs17778257, rs2895795, rs2053044, rs12654778, rs11959427, rs1042711, rs1042713, rs1042714, rs1800888, and rs1042718).


11 rs2895795

Eleven polymorphisms will be selected for genotyping from within the ADRB2 coding region and up to about 5 kb 5' Codon 1 (rs11958940, rs17778257, rs2895795, rs2053044, rs12654778, rs11959427, rs1042711, rs1042713, rs1042714, rs1800888, and rs1042718).



HPO Nodes


HPO:
Asthma
Genes 66
ELOVL4 FLG COL5A1 LIFR COL5A2 TGIF1 LIG4 CDSN ERCC2 BCL11B CARMIL2 COMT SEC24C ALMS1 ARVCF NKX2-1 DOCK8 GLI2 TRAIP NFKB2 CFTR TBX21 SCN4A UFD1 GAS1 PEPD SHH BBS1 GTF2H5 PEX5 CASP8 FGF8 CARD11 FGFR1 TDGF1 PLCG2 LRBA SIK3 COX4I2 IDS PTCH1 RREB1 FOXH1 SIX3 DLL1 ADA SUFU NODAL NSUN2 GRHL2 TALDO1 NEK9 CCDC151 JMJD1C DISP1 TBX1 PGM3 SDHD CDON HIRA ZIC2 GP1BA GP1BB COL1A1 SPINK5 GP9