SNPMiner Trials: Clinical Trial Report

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Report for Clinical Trial NCT01989351

Developed by Shray Alag, 2019.

SNP Clinical Trial Gene

LA PREDISPOSIZIONE AL DOLORE PERSISTENTE POST OPERATORIO IN AMBITO ORTOPEDICO: ASPETTI GENETICI

The study purpose is to examine polymorphism of genes associated to post-operative persistent pain and to verify the possible association between genotype phenotype and ADRB2 polymorphism in orthopaedic surgery. The primary aim is to evaluate the expression of ADBR2 in VAS>4 patients and to compare it to those with VAS<4.

NCT01989351 Chronic Pain

MeSH: Chronic Pain

HPO: Chronic pain

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Primary Outcomes

Measure: Frequency of SNPs rs12654788 and rs1042713 of ADBR2 gene in patients who complain persistent pain 4 months postoperatively compared to chronic pain free patients.

Time: 4 months after surgery

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Secondary Outcomes

Measure: Expression frequency of OPRM1, COMT, IL1Ra

Time: 6, 12, 24, 48 hours

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Measure: Serum concentration of TNFα, TGFβ, IFNγ, IL-6 and IL-10 obtained with ELISA system

Time: 6, 12, 24 and 48 hours postoperatively

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Time Perspective: Prospective

Cohort

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There are 2 SNPs

SNPs

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1 rs1042713

Frequency of SNPs rs12654788 and rs1042713 of ADBR2 gene in patients who complain persistent pain 4 months postoperatively compared to chronic pain free patients.. null.

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2 rs12654788

Frequency of SNPs rs12654788 and rs1042713 of ADBR2 gene in patients who complain persistent pain 4 months postoperatively compared to chronic pain free patients.. null.

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HPO Nodes

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HPO:

Chronic pain

Genes 3

TGFB2 FLVCR1 ATXN3