SNPMiner Trials by Shray Alag


SNPMiner Trials: Clinical Trial Report


Report for Clinical Trial NCT01490424

Developed by Shray Alag, 2019.
SNP Clinical Trial Gene

Association Between TREM-1 Gene Polymorphisms and Prognosis in Sepsis Patient

Triggering receptor expressed on myeloid cells-1 (TREM-1) is a cell surface receptor expressed on neutrophils and monocytes. TREM-1 acts to amplify inflammation and serves as a critical mediator of inflammatory response in the context of sepsis. Blocking of TREM-1 can protect against sepsis in mice. This study was designed to investigate whether TREM-1 genomic variations were associated with the prognosis of sepsis. We sequenced 30 sepsis patients with TREM-1 gene of four exons by PCR sequencing. When analyzing the results of sequencing, we found two gene polymorphisms located in exon-2 and exon-4, respectively. Compare with the NCBI dbSNP and Hapmap database, one polymorphisms located in exon-2 is non-synonymous variation rs2234237(Ser25Thr), the other one located in exon-4 is synonymous variation rs2234246. Two common polymorphisms (rs2234237,rs2234246) within the TREM-1 gene were detected in 80 patients with severe sepsis and in 80 healthy control subjects. This study was explored that whether or not polymorphisms detected within the TREM-1 gene may play a major role in the predisposition to prognosis of sepsis in a Chinese Han cohort.

NCT01490424 Sepsis
MeSH: Sepsis
HPO: Sepsis


Primary Outcomes

Description: The survival time of patients more than 28days is defined as survival. The survival time of patients less than 28days is defined as death

Measure: Patients Outcome

Time: 28 days

Time Perspective: Prospective

Case Control


There are 3 SNPs

SNPs


1 rs2234237

Two common polymorphisms (rs2234237,rs2234246) within the TREM-1 gene were detected in 80 patients with severe sepsis and in 80 healthy control subjects.


2 rs2234237r25r

Compare with the NCBI dbSNP and Hapmap database, one polymorphisms located in exon-2 is non-synonymous variation rs2234237(Ser25Thr), the other one located in exon-4 is synonymous variation rs2234246.


3 rs2234246

Compare with the NCBI dbSNP and Hapmap database, one polymorphisms located in exon-2 is non-synonymous variation rs2234237(Ser25Thr), the other one located in exon-4 is synonymous variation rs2234246.

Two common polymorphisms (rs2234237,rs2234246) within the TREM-1 gene were detected in 80 patients with severe sepsis and in 80 healthy control subjects.



HPO Nodes


HPO:
Sepsis
Genes 68
CYBB RMRP RAG1 RAG2 TGM1 LIG4 SEMA3D NIPAL4 SEMA3C TCF3 MYH11 SAMD9 ATP7A MYLK WAS GALT WIPF1 G6PC3 HLA-B SULT2B1 DCLRE1C MNX1 NRTN ABCA12 CXCR4 PIK3R1 IGHM CYBC1 BTK NFKB2 NCF1 BLNK APC LRRC8A ELANE ACTG2 LMOD1 CYP4F22 AK2 CD79A CD79B ALOXE3 IKZF1 NCF2 NCF4 SERAC1 LIPN CHD7 IGLL1 CTNNB1 PLEC RET ECE1 ADA IL2RG ITGB4 GDNF COG4 ALOX12B MMUT EDN3 EDNRB IL7R FERMT3 TFRC CYBA FOXP3 SDR9C7