SNPMiner Trials: Clinical Trial Report
Report for Clinical Trial NCT00897455
Developed by Shray Alag, 2019.
SNP Clinical Trial Gene
RATIONALE: Studying samples of DNA in the laboratory from women who are BRCA1/BRCA2 mutation
carriers may help doctors learn more about cancer and identify biomarkers related to cancer.
PURPOSE: This research study is looking at breast cancer risk in women who are BRCA1/BRCA2
mutation carriers.
Name: DNA analysis
Type: Genetic
Name: mutation analysis
Type: Genetic
Name: polymorphism analysis
Type: Genetic
Name: laboratory biomarker analysis
Type: Other
Name: evaluation of cancer risk factors
Type: Procedure
Primary Outcomes
Measure: Identification of potential genetic modifiers of breast cancer risk
There are 3 SNPs
SNPs
1 rs16942
Previously collected DNA samples are analyzed for genetic variants in selected candidate
genes (rs16942 in BRCA1, rs2237060 in RAD50, "SNP3", and rs2241193 in IGFBP5).
2 rs2237060
Previously collected DNA samples are analyzed for genetic variants in selected candidate
genes (rs16942 in BRCA1, rs2237060 in RAD50, "SNP3", and rs2241193 in IGFBP5).
3 rs2241193
Previously collected DNA samples are analyzed for genetic variants in selected candidate
genes (rs16942 in BRCA1, rs2237060 in RAD50, "SNP3", and rs2241193 in IGFBP5).
HPO Nodes
HPO:Breast carcinoma
Genes 51
RAD51 RAD51C RAD51D CDKN2A KRAS MRE11 SLC22A18 STK11 MSH6 KLLN BRIP1 BRCA1 ATR BRCA2 PIK3CA PPM1D POLD1 NTHL1 POLE ESR1 WRN CHEK2 APC BARD1 MLH1 NBN COL14A1 AKT1 PRKN MSH2 FGFR2 IDH1 IDH2 CTNNB1 RB1CC1 PTEN MDM2 AAGAB CDH1 RNF43 PALLD PALB2 OPCML SEC23B TP53 SDHB SDHC SDHD SMAD4 TWIST1 RAD50 hr>Neoplasm of the breast
Genes 73
RAD51 RAD51C RAD51D CDKN2A KRAS CDKN2B CDKN2D MRE11 SLC22A18 STK11 MSH6 RASGRP1 KLLN BRIP1 MGMT BRCA1 LMNA ATR ACD BRCA2 PIK3CA PPM1D POLD1 NTHL1 POLE ESR1 POT1 MC1R MITF WRN CHEK2 APC BARD1 MLH1 PRKAR1A CASP10 NBN PRKCD COL14A1 AKT1 C11ORF95 PRKN RELA MSH2 FGFR2 IDH1 GNAS IDH2 CTNNB1 RB1CC1 PTEN MDM2 FAS FASLG AAGAB CDH1 TERT RNF43 PALLD PALB2 OPCML TERF2IP PRLR SEC23B TP53 SDHB SDHC SDHD SMAD4 BAP1 CDK4 TWIST1 RAD50 hr>