SNPMiner Trials: SNP Report
Report for SNP rs2895795
Developed by Shray Alag, 2019.
SNP Clinical Trial Gene
There is one clinical trial.
The hypothesis to be tested is that acutely ill asthmatics who do not resolve their attacks
following standard doses of albuterol and require admission to hospital have single
nucleotide polymorphisms of their B2 adrenergic receptors that lower B2 agonist responsivity.
NCT01016444 Acute Asthma
Eleven polymorphisms will be selected for genotyping from within the ADRB2 coding region and
up to about 5 kb 5' Codon 1 (rs11958940, rs17778257, rs2895795, rs2053044, rs12654778,
rs11959427, rs1042711, rs1042713, rs1042714, rs1800888, and rs1042718).
Primary Outcomes Measure
: B2AR polymorphisms associated with albuterol responsiveness in acute asthma. Time
: ~ 1 hour following 3 doses of albuterol Q 20 min
Secondary Outcomes Measure
: B2AR haplotypes Time
: ~ 1hr post 3 doses of albuterol
Genes 66ELOVL4 FLG COL5A1 LIFR COL5A2 TGIF1 LIG4 CDSN ERCC2 BCL11B CARMIL2 COMT SEC24C ALMS1 ARVCF NKX2-1 DOCK8 GLI2 TRAIP NFKB2 CFTR TBX21 SCN4A UFD1 GAS1 PEPD SHH BBS1 GTF2H5 PEX5 CASP8 FGF8 CARD11 FGFR1 TDGF1 PLCG2 LRBA SIK3 COX4I2 IDS PTCH1 RREB1 FOXH1 SIX3 DLL1 ADA SUFU NODAL NSUN2 GRHL2 TALDO1 NEK9 CCDC151 JMJD1C DISP1 TBX1 PGM3 SDHD CDON HIRA ZIC2 GP1BA GP1BB COL1A1 SPINK5 GP9